The J6JFH1 Strain of Hepatitis C Virus Infects Human B-Cells with Low Replication Efficacy

Viral Immunology , Vol. 0, No. 0.
Source: Viral Immunology - Category: Allergy & Immunology Tags: article Source Type: research

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CONCLUSIONS: Our findings suggest a common pathogenetic mechanism in EMC, HCV-MC and primary Sjögren's syndrome, consisting of autoantigen-driven clonal expansion and exhaustion of selected RF-producing B-cells. The more massive clonal expansion in HCV-MC may be due to co-stimulatory signals provided by the virus. PMID: 31969220 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Transfusion related hepatitis C(HCV) is rare in the west, in the developing world, it remains a challenge. Children with hematological malignancies are especially vulnerable due to large number of blood components received. They often develop active hepatitis due to immunocompromised status and concurrent hepatic insults from chemotherapy and iron overload. Stem cell transplant(SCT) further increases hepatic risk due to veno-occlusive disease(VOD) and hepatic graft versus host disease(GVHD).Direct acting antivirals(DAA) have revolutionized treatment of HCV.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 536 Source Type: research
Seki Okazaki Nonalcoholic steatohepatitis (NASH)-related hepatocellular carcinoma (HCC) sometimes occurs in mildly fibrotic livers, while HCC incidence in NASH-related cirrhosis is lower than and less predictable than in hepatitis C virus (HCV)-related cirrhosis. Transforming growth factor (TGF)-β signaling in hepatocytic nuclei is implicated in fibrosis and carcinogenesis. TGF-βtype I receptor (TβRI) and c-Jun N-terminal kinase (JNK) differentially phosphorylate the mediator Smad3, resulting in 2 distinct phospho-isoforms: C-terminally phosphorylated Smad3 (pSmad3C) and linker-phosphoryl...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
OMICS: A Journal of Integrative Biology, Ahead of Print.
Source: OMICS: A Journal of Integrative Biology - Category: Biology Authors: Source Type: research
ConclusionThe favorable linkage to care and cure outcomes in our study suggests that homeless persons may be more likely to engage in HCV screening and treatment when these services are located in the community for their use. Our study further lends support to the efficacy of care coordination programs to encourage movement through the HCV care continuum in vulnerable populations.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
The opioid epidemic in the U.S. is driving a simultaneous epidemic of infectious diseases— including HIV, hepatitis C virus (HCV) and bacterial infections, and sexually transmitted infections— but workforce shortages, stigma, and administrative burdens are preventing the integration of opioid use disorder (OUD) and infectious disease services, says a new report from the National Academies of Sciences, Engineering, and Medicine. It recommends a number of state and federal policy actions to address those barriers, including removing insurance requirements on prescribing medications for OUD (i.e., buprenorphine), ...
Source: News from the National Academies - Category: Science Source Type: news
The authors describe the principles behind and approach to HCV resistance testing and consider evidence from in vitro studies, clinical trials and real world cohorts on the impact of HCV resistance on treatment outcomes for particular DAA regimens. Five scenarios are identified in the UK and similar settings, where, in the Group's opinion, resistance testing should be performed.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
In conclusion, the molecular mechanism of anti-HCC of B. batryticatus can be related to the tumor microenvironment to some extent. B. batryticatus may exert its anti-cancer effects and improve prognosis of patients by regulating macrophages M1 in VIR and NVIR through acting on different targets.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Ifeorah IM, Bakarey AS, Akubo AO, Onyemelukwe FN Abstract Hepatitis C virus (HCV) is associated with liver complicated diseases resulting in end-stage hepatocellular carcinoma. Although vertical transmission from mother to child serves as one of the routes of HCV acquisition in children, yet HCV infection in pregnant women and children is still underappreciated in sub-Saharan Africa. Therefore, this study investigated the burden of HCV, associated risk factors, and viremia among antenatal and postnatal clinic attendees in the rural and urban communities of Kogi State, Nigeria. Atotal of 176 blood samples w...
Source: Journal of Immunoassay and Immunochemistry - Category: Biochemistry Tags: J Immunoassay Immunochem Source Type: research
AbstractCoping has emerged as a vital indicator among patients in the chronic conditions. The current study examined the role of demographic characteristics (such as age, education, gender, marital status, residential background, family type and number of children) in adoption of coping (emotion-focused, problem-solving, religious –spiritual) strategies for nursing among hepatitis patients. A sample of 500 patients (of hepatitis C) was drawn from five most populous districts (Lahore, Faisalabad, Rawalpindi, Gujranwala and Multan) of Punjab, Pakistan, by using Epi Info software with an alpha level of 0.03. The data we...
Source: Journal of Religion and Health - Category: Medical Ethics Source Type: research
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