Handy paediatric dermatology

Dermatological hand signs are common and can be benign (with or without treatment implications), linked to a change in patient's behaviour or herald more severe systemic conditions (dermatomyositis). Despite the peculiarity of underlying diseases, their visual appearances may overlap and sometimes be deceptive. It is therefore important for clinicians to be aware of the possible similarities in such diverse conditions, in order to make a correct diagnosis and target treatment. Which would be the most likely diagnosis for each image based on the cases below: Gottron's papules Psoriasis Cutaneous T-cell lymphoma Chewing pads Knuckle calluses Herpetic lesions Idiopathic/familial knuckle pads Cold burns (frost bites) Common warts Occupational lesions Patient 1 We evaluated a 17-year-old girl with dark phototype with an upper respiratory tract infection. Physical examination incidentally revealed plaque lesions located only at the extensor...
Source: Archives of Disease in Childhood - Education and Practice - Category: Pediatrics Authors: Tags: Dermatophile Source Type: research

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We present two cases which are specific for unusual location of Burkitt lymphoma in the colon and stomach, in immunocompetent patients with negative Epstein-Barr virus tests. Also, one of the patients presented is one of the oldest ever reported with abdominal Burkitt lymphoma, while the other patient is an example of diagnostic difficulties in distinguishing Burkitt lymphoma from similar lymphomas. Due to the rapidly growing tumors and urgent need for cytoreductive surgery, it is crucial to consider the diagnosis of Burkitt lymphoma even in atypical localizations or absence of the common risk factors associated with Burki...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Conclusion: Increased IFN-κ in psoriasis may be caused by injured cells-released nucleic acids, increased IFN-γ and self-activation. Its enhancement may contribute to the etiology of the disease by enhancing TNFA and IL17A gene expression. PMID: 31819584 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Authors: Grajdeanu IA, Statescu L, Vata D, Popescu IA, Porumb-Andrese E, Patrascu AI, Taranu T, Crisan M, Solovastru LG Abstract Plaque psoriasis is a chronic, immune-mediated disease, which has a multifactorial etiopathogenesis. Practical non-invasive techniques to monitor plaque psoriasis progression and treatment are necessary. Imaging techniques available for psoriasis assessment may vary in terms of resolution, depth of penetration and visual representation. This review summarizes the current developments in the field of psoriasis non-invasive imaging techniques, such as dermoscopy, conventional ultrasound and...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
I'm currently in medical school right now, and I would guesstimate that literally about half of my class has a parent whose a doctor. Of that percentage, I would say about 10% of them have two parents that are doctors. So, just curious...and I'd love to hear from people who have parents that are doctors..but what REALLY made you go into medicine despite knowing the long, hard road that lies ahead of you? You were never scared away from being a doctor, after seeing all the hours mom/dad... If doctors are so miserable &burnt out, why do so many of their kids still want to go to medical school?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Medical Students - MD Source Type: forums
Conditions:   Stem Cell Transplant Complications;   Myeloma;   Lymphoma;   Allogeneic and Autologous Stem Cell Transplant Interventions:   Other: physical therapy consult;   Other: Cognitive Assessment;   Other: Cancer Aging Research Group (CARG) assessment;   Other: Medication Review;   Other: Nutrition assessment;   Other: Laboratory studies;   Other: Patient satisfaction questionnaire;   Other: Physician Q uestionnaire;   Other: Pati...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Burns;   Multiple Organ Failure;   Shock;   Organ Dysfunction Syndrome, Multiple;   Renal Dysfunction;   Cytokine Storm Intervention:   Device: CytoSorb haemadsorption device Sponsor:   University of Pecs Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A 29-year-old woman with stage IIBX classic Hodgkin's lymphoma presented with a 5.1  × 7.6-cm (mass to mediastinal ratio 0.34) anterior mediastinal mass and additional involvement of the subcarinal, posterior mediastinal, and right infraclavicular lymph nodes (Fig. 1). The patient was otherwise healthy, a lifelong nonsmoker, and European Cooperative Oncology Group performance s tatus 0. She had a National Comprehensive Cancer Network International Prognostic Score of 1. She received 2 cycles of adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD), and interim positron emission tomography demonstr...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
The patient in question, with both B symptoms and bulky disease, belongs to an intermediate group in which disease can be considered advanced and treated with bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone if we follow the German Hodgkin's Study HD 11 criteria.1 Many others still treat this group as an early unfavorable disease using doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD). This is particularly important in explaining the treatment options presented here.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
This young patient could be classified as having unfavorable early-stage Hodgkin lymphoma (HL) per the European Organization for Research and Treatment of Cancer H10 study or advanced HL per UK Response-Adapted Therapy for Advanced Hodgkin Lymphoma study, both adaptive therapy trials commencing with 2  cycles of Doxorubicin, bleomycin, vinblastine, and dacarbazine.1
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Gene Variant in the NF-κB Pathway Inhibitor NFKBIA Distinguishes Patients with Psoriatic Arthritis within the Spectrum of Psoriatic Disease. Biomed Res Int. 2019;2019:1030256 Authors: Coto-Segura P, Coto E, González-Lara L, Alonso B, Gómez J, Cuesta-Llavona E, Queiro R Abstract Background and Aims: The NF-κB pathway has been implicated in the genetic aetiology of psoriatic disease. However, since most patients with arthritis have psoriasis, discerning the genetic contributions to both aspects of psoriatic disease is not easy. Our aim was to study the association of common pol...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
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