Effect of structure and composition of nickel(II) complexes with salicylidene Schiff base ligands on their DNA/protein interaction and cytotoxicity.

Effect of structure and composition of nickel(II) complexes with salicylidene Schiff base ligands on their DNA/protein interaction and cytotoxicity. J Inorg Biochem. 2014 Apr 26;137C:101-108 Authors: Li P, Niu M, Hong M, Cheng S, Dou J Abstract Three new salicylidene Schiff base nickel(II) complexes [Ni(L(1))(CH3COOH)2]2 (1), [Ni2(L(1))2(CH3OH)] (2), [Ni(L(2))2]ยท3H2O (3) {H2L(1)=N,N'-bis(salicylidene)-3,6-dioxa-1,8-diaminooctane, HL(2)=2-ethyl-2-(2-hydroxybenzylideneamino)propane-1,3-diol} were synthesized and characterized fully by structural, analytical, and spectral methods. The single-crystal X-ray structures of complexes 1 and 2 exhibit the symmetrical ligands coordinated to the nickel(II) ion in a tetradentate fashion via ONNO donor atoms, while the unsymmetrical ligand L(2) presented a ONO tridentate coordination mode in complex 3. The nickel(II) ions lie in the six-coordinated octahedral environment for the mononuclear complexes 1 and 3, along with dinuclear complex 2. The interaction of the complexes with calf thymus DNA (CT-DNA) has been explored by absorption and emission titration methods, which revealed that complexes 1-3 could interact with CT-DNA through intercalation. The interactions of the complexes with bovine serum albumin (BSA) were also investigated using UV-Vis, fluorescence and synchronous fluorescence spectroscopic methods. The results indicated that all of the complexes could quench the intrinsic fluorescen...
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research