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Recurrent urinary tract infections: prevention of recurrence with intravesical instillations of chondroitin sulfate and hyaluronic acid.

DISCUSSION: Patients included in the protocol of instillation improved significantly their quality of life; in addition, to a considerable extent new urinary infections were not presented, being milder when they presented. PMID: 28300032 [PubMed - in process]
Source: Archivos Espanoles de Urologia - Category: Urology & Nephrology Tags: Arch Esp Urol Source Type: research

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This evidence summary outlines the best available evidence for a new intravenous antimicrobial, ceftazidime/avibactam (Zavicefta). It is indicated for treating complicated intra-abdominal infections,complicated urinary tract infections, including pyelonephritis,hospital ‑acquired pneumonia, including ventilator‑associated pneumonia and infections caused by aerobic gram‑negative organisms in adults with limited treatment options.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
The extreme hypertonicity of the renal medulla plays a central role in regulating volume status. A recent publication in Cell has identified a novel role for the high sodium environment and the local epithelial cells in the recruitment of mononuclear phagocytes, potentially contributing to the defense against ascending urinary tract infection.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Nephrology Digest Source Type: research
AbstractBackground Urinary tract infections (UTIs) are among the most common bacterial infections. Options for initial treatment of pyelonephritis or UTI requiring hospitalization include levofloxacin (LVF) or extended-spectrum cephalosporins. Globally, uropathogenicEscherichia coli resistance rates to fluoroquinolones have increased in recent years.Objective To compare clinical outcomes of patients receiving ceftriaxone (CTX) to those who received LVF empirically for the treatment ofE.coli UTI.Setting 433-bed community hospital in Lexington, KY.Methods Retrospective, single center, cohort study of adults with a urine cult...
Source: International Journal of Clinical Pharmacy - Category: Drugs & Pharmacology Source Type: research
In this study, we examined E. faecalis-mediated subversion of macrophage activation. We observed that E. faecalis actively prevents NF-B signaling in mouse RAW264.7 macrophages in the presence of Toll-like receptor agonists and during polymicrobial infection with Escherichia coli. E. faecalis and E. coli coinfection in a mouse model of catheter-associated urinary tract infection (CAUTI) resulted in a suppressed macrophage transcriptional response in the bladder compared to that with E. coli infection alone. Finally, we demonstrated that coinoculation of E. faecalis with a commensal strain of E. coli into catheterized bladd...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Bacterial Infections Source Type: research
AbstractPrevious studies have shown controversial results of factors associated with short-term mortality in patients with extended-spectrum beta-lactamase (ESBL)-producingE. coli bacteremia and no research has investigated the impact of the geriatric assessment criteria on short-term mortality. Our objective was to determine whether dementia and walking ability are associated with 30-day mortality in patients with ESBL-producingE. coli bacteremia. All blood bottle cultures, analyzed from January 2008 to April 2015, in the Bacteriology Department of a 2,600-bed, university-affiliated center, Nantes, France, were retrospect...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
This study will clarify the clinical value of UC-MSCs in preventing DGF and acute rejection simultaneously in deceased-donor renal transplantation, and provide evidence as to whether allogeneic MSCs can be used as clinically feasible and safe induction therapy.Trial registrationClinicalTrials.gov,NCT02490020. Registered on 29 June 2015.
Source: Trials - Category: Research Source Type: clinical trials
Implementation of clinical practice guidelines (CPGs) is intended to promote the optimal management approach outcomes for a given clinical entity. Although numerous pediatric urinary tract infections (PUTI) CPGs have been published over the past decade, the inherent inconsistencies in their recommendations have led to confusion and difficulty in their implementation. Okarska-Napiera ła et al. [1] have addressed the aforementioned concerns by comparing the available guidelines on PUTI, and summarized the similarities and differences of the recommendations.
Source: Journal of Pediatric Urology - Category: Urology & Nephrology Authors: Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Individuals with a spinal cord injury (SCI), despite specialized rehabilitation and good health care, have a reduced life expectancy. Infectious diseases, such as pneumonias, infected pressure sores and urinar...
Source: Immunity and Aging - Category: Geriatrics Authors: Tags: Research Source Type: research
Early signs of canine transitional cell carcinoma (TCC) are frequently assumed to be caused by other lower urinary tract diseases (LUTD) such as urinary tract infections, resulting in late diagnosis of TCC whi...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
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