AR CAG repeat and autoimmunity in lupus

Clinical and experimental evidence support a role for gonadal steroids in modulating the expression and course of autoimmune diseases such as lupus. It is not known if inherited variation in sensitivity to circulating androgenic hormones could influence the manifestations of such a disease. Olsen and colleagues found that shorter AR CAG repeat lengths in lupus subjects correlated with a higher Systemic Lupus Erythematosus Disease Activity Index score, higher ANA levels, expression of a broader array of IgG autoantibodies, more severe clinical manifestations, and more exuberant humoral autoimmunity. These findings suggest a role for genetically determined sensitivity to androgens as a modulator of autoimmune processes.   Read the full article at Olsen et al. (2014) Endocrine Connections 3 99–109; DOI:10.1530/EC-14-0039
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Publication date: Available online 14 August 2018Source: Autoimmunity ReviewsAuthor(s): Kassem Sharif, Abdulla Watad, Louis Coplan, Benjamin Lichtbroun, Alec Krosser, Michael Lichtbroun, Nicola Luigi Bragazzi, Howard Amital, Arnon Afek, Yehuda ShoenfeldAbstractStress is defined as the pscyophysiological reaction in which the steady state is disturbed or threatened. Stress is not always perceived as a negative response. Stress results when environmental demands exceed an individuals' adaptive capacities. Autoimmune diseases are heterogeneous group of chronic diseases which occur secondary to loss of self antigen tolerance. ...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
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Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
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Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - Category: Pathology Source Type: research
dling F Abstract INTRODUCTION:  Systemic lupus erythematodes (SLE) represents an autoimmune disease with a highly variable clinical course affecting numerous organs. Hepatic manifestation seems to be rare. It is not clear whether hepatic disease in SLE is of any prognostic importance or whether it correlates with disease activity. METHODS:  Our patient cohort included 172 patients with proven SLE, all treated at Bogenhausen Hospital between 01.2009 and 12.2015. Retrospectively, all admissions as inpatients and outpatients were analyzed (n = 671; mean 3.9 per patient). Liver damage was diagnosed ...
Source: Zeitschrift fur Gastroenterologie - Category: Gastroenterology Authors: Tags: Z Gastroenterol Source Type: research
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Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Autoimmune disorders are a category of diseases in which the immune system attacks healthy cells as a result of a dysfunction of the acquired immune system. Clinical presentation and diagnosis are disease specific and often correspond with the degree of inflammation, as well as the systems involved. Treatment varies based on the specific disease, its stage of presentation, and patient symptoms. The primary goal of treatment is to decrease inflammation, minimize symptoms, and lessen the potential for relapse. Graves disease, Hashimoto thyroiditis, rheumatoid arthritis, Crohn disease, ulcerative colitis, systemic lupus eryth...
Source: Nursing Clinics of North America - Category: Nursing Authors: Source Type: research
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Source: dukehealth.org: Duke Health News - Category: Consumer Health News Authors: Source Type: news
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Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
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Source: Cell - Category: Cytology Source Type: research
THURSDAY, Aug. 2, 2018 -- Heart disease is a leading cause of death in patients with the autoimmune illness lupus. Now, research suggests high-tech scans can spot cardiac issues early. The scans can detect heart abnormalities even before patients...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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