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AR CAG repeat and autoimmunity in lupus

Clinical and experimental evidence support a role for gonadal steroids in modulating the expression and course of autoimmune diseases such as lupus. It is not known if inherited variation in sensitivity to circulating androgenic hormones could influence the manifestations of such a disease. Olsen and colleagues found that shorter AR CAG repeat lengths in lupus subjects correlated with a higher Systemic Lupus Erythematosus Disease Activity Index score, higher ANA levels, expression of a broader array of IgG autoantibodies, more severe clinical manifestations, and more exuberant humoral autoimmunity. These findings suggest a role for genetically determined sensitivity to androgens as a modulator of autoimmune processes.   Read the full article at Olsen et al. (2014) Endocrine Connections 3 99–109; DOI:10.1530/EC-14-0039
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Publication date: April 2018 Source:Biomedicine & Pharmacotherapy, Volume 100 Author(s): Mehdi Soltanzadeh-Yamchi, Mehdi Shahbazi, Saeed Aslani, Mousa Mohammadnia-Afrouzi MicroRNAs (miRNAs) are small RNA molecules with regulatory functions on the expression of genes through binding directly to target messenger RNA (mRNA) transcripts, eventuating in gene expression suppression via translational hindrance and/or target mRNA cleavage. These molecules have been established to participate in numerous critical cellular settings, including differentiation, development, and function of immune cells. As an important suppressor...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Summary Antiphospholipid syndrome (APS) is an autoimmune disease characterized by antiphospholipid antibodies (aPL) associated with thrombosis and/or pregnancy morbidity. Most APS events are directly related to thrombotic events, which may affect small, medium or large vessels. Other clinical features like thrombocytopenia, nephropathy, cardiac valve disease, cognitive dysfunction and skin ulcers (called non-criteria manifestations) add significant morbidity to this syndrome and represent clinical situations that are challenging. APS was initially described in patients with systemic lupus erythematosus (SLE) but it can occ...
Source: Revista da Associacao Medica Brasileira - Category: General Medicine Source Type: research
Publication date: Available online 7 February 2018 Source:Autoimmunity Reviews Author(s): Jean-François Augusto, Marie-Elise Truchetet, Nicolas Charles, Patrick Blanco, Christophe Richez Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immunological pathways. Recently, several studies have suggested an implication of Immunoglobulin E (IgE) in the pathophysiology of SLE. In the Lyn−/− and FcγIIB−/−.Yaa lupus mouse models, autoreactive IgE activate basophils, and promote a Th2 environment with, subsequently, production of autoantibodies by plasma cell...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ObjectivesIn multiple sclerosis (MS), magnetic resonance imaging (MRI) is a sensitive tool for detecting white matter lesions, but its diagnostic specificity is still suboptimal; ambiguous cases are frequent in clinical practice. Detection of perivenular lesions in the brain (the “central vein sign”) improves the pathological specificity of MS diagnosis, but comprehensive evaluation of this MRI biomarker in MS‐mimicking inflammatory and/or autoimmune diseases, such as central nervous system (CNS) inflammatory vasculopathies, is lacking. In a multicenter study, we assessed the frequency of perivenular lesions ...
Source: Annals of Neurology - Category: Neurology Authors: Tags: Research Article Source Type: research
Authors: Olson SW, Lee JJ, Poirier M, Little DJ, Prince LK, Baker TP, Edison JD, Abbott KC Abstract Background: The subclinical pathophysiology of proliferative lupus nephritis (PLN) has not been fully elucidated. Myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) is associated with PLN, but prediagnostic levels have not been reported. Methods: We performed a retrospective case-control Department of Defense Serum Repository (DoDSR) study comparing MPO-ANCA levels in longitudinal prediagnostic serum samples for 23 biopsy confirmed proliferative lupus nephritis (PLN) patients to DoDSR identified age,...
Source: Autoimmune Diseases - Category: Allergy & Immunology Tags: Autoimmune Dis Source Type: research
Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease that can affect a variety of organ systems. With treatment, cSLE can be well managed but a subgroup of youth with cSLE (~30%) experience debilitating symptoms including pain, fatigue, and sleep dysregulation, despite well controlled disease. Cognitive behavioral therapy (CBT) can be effective in managing pain, sleep difficulties, and fatigue in a variety of medical conditions. However, a tailored approach to meet the needs of a cSLE population has not yet been developed.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
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Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Research Article Source Type: research
This article is protected by copyright. All rights reserved. PMID: 29442374 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Eur J Immunol Source Type: research
Abstract MicroRNAs (miRNAs) are small RNA molecules with regulatory functions on the expression of genes through binding directly to target messenger RNA (mRNA) transcripts, eventuating in gene expression suppression via translational hindrance and/or target mRNA cleavage. These molecules have been established to participate in numerous critical cellular settings, including differentiation, development, and function of immune cells. As an important suppressor cell of immune system, regulatory T cells (Tregs) are important in modulating the immune homeostasis as well as tolerance to self-antigens. Despite identific...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Tags: Biomed Pharmacother Source Type: research
Authors: Nedoszytko B, Sokołowska-Wojdyło M, Renke J, Lange M, Trzonkowski P, Sobjanek M, Szczerkowska-Dobosz A, Niedoszytko M, Górska A, Romantowski J, Skokowski J, Kalinowski L, Nowicki RJ Abstract Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of several skin diseases like psoriasis, atopic dermatitis, systemic lupus erythematosus, cutaneous T-cell lymphomas, and skin cancer and is also important in rheumatoid arthritis, diabetes and other auto...
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
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