Log in to search using one of your social media accounts:

 

AR CAG repeat and autoimmunity in lupus

Clinical and experimental evidence support a role for gonadal steroids in modulating the expression and course of autoimmune diseases such as lupus. It is not known if inherited variation in sensitivity to circulating androgenic hormones could influence the manifestations of such a disease. Olsen and colleagues found that shorter AR CAG repeat lengths in lupus subjects correlated with a higher Systemic Lupus Erythematosus Disease Activity Index score, higher ANA levels, expression of a broader array of IgG autoantibodies, more severe clinical manifestations, and more exuberant humoral autoimmunity. These findings suggest a role for genetically determined sensitivity to androgens as a modulator of autoimmune processes.   Read the full article at Olsen et al. (2014) Endocrine Connections 3 99–109; DOI:10.1530/EC-14-0039
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

Related Links:

This study aimed to perform a systematic review and meta-analysis on the association between vitamin D levels and AA.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Research letter Source Type: research
Discussion Sjögren Syndrome (SS) is named for Swedish ophthalmologist Henrik Sjögren who published a case series in 1933 describing patients with dry eyes and arthritis. SS is a “chronic autoimmune inflammatory exocrinopathy” that is characterized by lymphocytic infiltration of the lacrimal and salivary glands and has various degrees of systematic involvement. Keratoconjunctivitis sicca and xerostomia are the main clinical symptoms. Sicca is a Latin word meaning dry. Dryness of the eyes and mouth without evidence of autoimmune disease is called Sicca syndrome or Sicca complex. SS can be primary or se...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
SummaryBased on their immunomodulatory properties, high‐dose intravenous immunoglobulins (IVIGs) are successfully used in the treatment of various dermatological autoimmune diseases, in particular pemphigus vulgaris and dermatomyositis. In autoimmune bullous diseases, IVIGs can be used in an adjuvant setting (second‐ or third‐line therapy) once combined immunosuppressive regimens have failed. In dermatomyositis, IVIGs may already be employed as an adjuvant second‐line therapy after failure of corticosteroid monotherapy. In scleromyxedema, IVIGs may be considered as first‐line treatment, given the lack of effectiv...
Source: JDDG - Category: Dermatology Authors: Tags: CME Article Source Type: research
This article is protected by copyright. All rights reserved. PMID: 29215161 [PubMed - as supplied by publisher]
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Eur J Immunol Source Type: research
Systemic lupus erythematosus (SLE) is the prototypic systemic autoimmune disease with variable multisystem involvement. Hematologic abnormalities involving multiple cell lineages are common in SLE. Lymphopenia was present in 75% among a large cohort of SLE patients and occurred more frequently than any other criterion used to classify the disease [1]. Anemia is estimated to occur in about 50% of patients [2]. While anemia of chronic disease and iron deficiency are quite common, autoantibody- or complement-mediated autoimmune hemolytic anemia are occasionally encountered [3].
Source: Seminars in Arthritis and Rheumatism - Category: Rheumatology Authors: Source Type: research
Conclusion: Silica can be associated with autoimmune diseases and this case brings the association with an autoimmune renal disease (vasculitis) in silicotic patients.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Occupational and Environmental Health Source Type: research
Conclusion: DAH is a severe disorder, with nonspecific presentation, caused by a wide spectrum of disease, as demonstrated by this series. Diagnosis requires high clinical suspicion and a thorough work-up.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research
CONCLUSIONS: Although adult-onset SLE had been associated with MECP2 gene variants, this gene is not associated with disease susceptibility in JSLE patients, implying the involvement of different susceptibility genes in the pathogenesis of SLE and JSLE. PMID: 29199882 [PubMed - as supplied by publisher]
Source: Fetal and Pediatric Pathology - Category: Pathology Tags: Fetal Pediatr Pathol Source Type: research
Publication date: Available online 10 November 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): May Y. Choi, Kelsey Flood, Sasha Bernatsky, Rosalind Ramsey-Goldman, Ann E. Clarke Systemic lupus erythematosus (SLE) is a chronic, systemic autoimmune disease characterized by autoantibody production, complement activation, and immune complex deposition. It predominantly affects young and middle-aged women. While improvements in the diagnosis and treatment of SLE have altered prognosis, morbidity and mortality rates remain higher than the general population. In addition to renal injury, cardiovascular ...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 6 November 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Natalia Vasquez-Canizares, Dawn Wahezi, Chaim Putterman Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by autoantibodies directed against numerous self-nuclear antigens. Because of the heterogeneous nature of lupus, it has been challenging to identify markers that are sensitive and specific enough for its diagnosis and monitoring. However, with the sequencing of the human genome, rapid development of high-throughput approaches has allowed for a better unders...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
More News: Autoimmune Disease | Endocrinology | Genetics | Hormones | Lupus