Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus

Publication date: Available online 18 March 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Habiba Al Safar, Sarah El Hajj Chehadeh, Laila Abdel-Wareth, Afrozul Haq, Herbert F. Jelinek, Gehad ElGhazali, Fatme Al Anouti At a prevalence rate close to 19.5%, the UAE has one of the highest rates of Type 2 Diabetes Mellitus (T2DM) in the world. Genome wide association studies (GWAS) have led to the identification of several genetic variants that are associated with T2DM. Recently, genes involved in vitamin D metabolism have gained interest because of the association between vitamin D deficiency (VDD) and increased risk for T2DM. Among these, the Vitamin D receptor (VDR) gene is a good candidate for T2DM susceptibility. The aim of this study was to investigate the association between VDR polymorphisms and T2DM among a representative sample of the Emirati population. In this cross sectional study, two hundred and sixty four patients with T2DM and ninety-one healthy controls were enrolled. The study population was genotyped for the three VDR gene mutations, TaqI (rs731236), FokI (rs2228570) and BsmI (rs1544410). VDR alleles and haplotypes were compared between patients and their healthy controls. The mean age of the T2DM cohort was 60±11.59years and 48.21±12.17years for the healthy controls. The G-allele and GG genotype of rs2228570 and T-allele and TT genotype of rs1544410 SNPs were associated with T2DM. In regards to T2DM-related metaboli...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research