Cyclophosphamide and its metabolite impact on  fertilization through mitochondrial dysfunction

Cyclophosphamide (CP) is a chemotherapeutic drug with a wide range of applications ranging from treatment of many gynecological cancers to various autoimmune diseases. As a sequela of CP exposure many women suffer from premature ovarian insufficiency and infertility. CP is metabolized in the liver to give stable toxic compound acrolein. Recently, we have established that CP and acrolein exposure causes deterioration of oocyte quality through changes in microtubule morphology and chromosomal alignment.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral Presentation Source Type: research