Dacomitinib ‐induced diarrhoea is associated with altered gastrointestinal permeability and disruption in ileal histology in rats

This study showed dacomitinib induces severe ileal damage accompanied by increased MCP1 expression, and gastrointestinal permeability in rats. The histological changes were most pronounced in the ileum, which was also the region with the highest relative expression of ErbB1. This article is protected by copyright. All rights reserved.

Source: International Journal of Cancer - March 18, 2017 Category: Cancer & Oncology Authors: Ysabella Z.A. Van Sebille, Rachel J. Gibson, Hannah R. Wardill, Kate R. Secombe, Imogen A. Ball, Dorothy M.K. Keefe, John W. Finnie, Joanne M. Bowen Tags: Research Article Source Type: research