Melanoma in Segmental Naevus Spilus: A Case Series and Literature Review.

Melanoma in Segmental Naevus Spilus: A Case Series and Literature Review. Acta Derm Venereol. 2017 Mar 15;: Authors: Boot-Bloemen MC, de Kort WJ, van der Spek-Keijser LM, Kukutsch NA Abstract is missing (Short communication). PMID: 28293687 [PubMed - as supplied by publisher]
Source: Acta Dermato-Venereologica - Category: Dermatology Authors: Tags: Acta Derm Venereol Source Type: research

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ConclusionWith simple network structure like RBFN and SVM we were able to obtain results better than other complex networks.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Conditions:   Melanoma;   Non-Small Cell Lung Cancer Intervention:   Drug: Single Arm Sponsors:   Cytosite Biopharma Inc.;   Massachusetts General Hospital;   University of Alabama at Birmingham Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, we investigated the expression of GLUT1 and the further glycolysis-related genes hexokinase 1 and 2 (HK1, HK2), lactate dehydrogenase A (LDH-A) and monocarboxylate transporters 1 and 4 (MCT1, MCT4) in eleven human melanoma cell lines under normoxic and hypoxic conditions. Furthermore, a set of 25 human malignant melanoma tissue samples was analyzed.Under hypoxic conditions, we could observe a significant upregulation of hypoxia-inducible factor 1 alpha (HIF-1a) target genes GLUT1, HK2 and LDH-A, but not MCT4. While under normoxic conditions the expression of glycolysis-related genes showed no correlation wit...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Abstract The complexity of the immune response and diversity of targets challenges conventional conceptual frameworks used in selecting and monitoring treatment with immune check-point inhibitors. The limitations of anatomic imaging in assessing response have been recognized. Varying patterns of response have been recognized. These patterns have different implications for the continuation and duration of therapy. Evidence supporting the role of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography as a prognostic biomarker and in characterizing response is presented. An added benefit of this appr...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: PET Clin Source Type: research
SURGICAL CLINICS OF NORTH AMERICA
Source: Surgical Clinics of North America - Category: Surgery Authors: Source Type: research
From the first description of an entity akin to our present understanding of Melanoma by Hippocrates of Cos in the fifth century bce, to the coinage of the term (melas “dark,” oma “tumor”) by Carswell in the nineteenth century, not much changed in the understanding or the management of this disease. The next century saw the application of increasingly radical surgery in an attempt to extirpate the disease without appreciable success in the outcomes for adv anced disease. From essentially useless chemotherapy in 1950 to 1980 with dacarbazine, it was not until the 1990s that first glimmer of hope was ...
Source: Surgical Clinics of North America - Category: Surgery Authors: Tags: Preface Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
The impact of intratumoral heterogeneity (ITH) and the resultant neoantigen landscape on T cell immunity are poorly understood. ITH is a widely recognized feature of solid tumors and poses distinct challenges related to the development of effective therapeutic strategies, including cancer neoantigen vaccines. Here, we performed deep targeted DNA sequencing...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
-Hui Lee Nan-Shan Chang Membrane hyaluronidase Hyal-2 supports cancer cell growth. Inhibition of Hyal-2 by specific antibody against Hyal-2 or pY216-Hyal-2 leads to cancer growth suppression and prevention in vivo. By immunoelectron microscopy, tumor suppressor WWOX is shown to be anchored, in part, in the cell membrane by Hyal-2. Alternatively, WWOX undergoes self-polymerization and localizes in the cell membrane. Proapoptotic pY33-WWOX binds Hyal-2, and TGF-β induces internalization of the pY33-WWOX/Hyal-2 complex to the nucleus for causing cell death. In contrast, when pY33 is downregulated and pS14 upreg...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Conclusions/interpretationThese results demonstrate a fundamental role for AIM2 in energy metabolism, inflammation and insulin resistance. Our studies establish a novel link between the innate immunity proteins, AIM2 and p202, and metabolism.
Source: Diabetologia - Category: Endocrinology Source Type: research
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