PRAS40 alleviates neurotoxic prion peptide-induced apoptosis via mTOR-AKT signaling.

CONCLUSION: PRAS40 inhibits mTORC1 hyperactivation and plays a key role in protecting cells against neurotoxic prion peptide-induced apoptosis. Thus, PRAS40 is a potential therapeutic target for prion disease.
PMID: 28294542 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - March 13, 2017 Category: Neuroscience Authors: Yang W, Yang LF, Song ZQ, Shah SZ, Cui YY, Li CS, Zhao HF, Gao HL, Zhou XM, Zhao DM Tags: CNS Neurosci Ther Source Type: research