Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in-coordination in rats with hepatic encephalopathy.

CONCLUSIONS: This study supports an interplay between cGMP-neuroinflammation and GABAergic neurotransmission in impairing motor coordination in PCS rats.
PMID: 28296282 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - March 10, 2017 Category: Neuroscience Authors: Agusti A, Hernández-Rabaza V, Balzano T, Taoro-Gonzalez L, Ibañez-Grau A, Cabrera-Pastor A, Fustero S, Llansola M, Montoliu C, Felipo V Tags: CNS Neurosci Ther Source Type: research