Unexpected heat shock element binding ability and tumor-killing activity of the combinatorial function domain of apoptin

In this study, we investigated the HSE-binding properties of the minimal functional region of apoptin. We showed that apoptin’s nuclear localization signals 1 and nuclear localization signals 2 represented functional regions that could bind with HSE and that this binding capacity was increased by polymers formed through the introduction of a leucine-rich stretch. Our data also showed that truncated combinatorial apoptin peptide has greater tumor-specific cell-killing activity and could be a potential antitumor agent.
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Preclinical Reports Source Type: research