Platelet-derived growth factor A mRNA in platelets is associated with the degree of hepatic fibrosis in chronic hepatitis C

CONCLUSIONS: A pathway mediated by overexpression of TGFB1 via PDGFA in megakaryocytes could be involved in the development of fibrosis.
Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

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Substance misuse and needle exchange patients in Newcastle will be given  “up to £25 of Greggs vouchers” if they present for a blood spot test for hepatitis C in a community pharmacy.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
Authors: Ruszel N, Kubisa B, Lisowski P, Piotrowska M, Kubisa MJ, Brykczyński M, Wojtyś M, Pieróg J, Czarnecka M, Wójcik J, Wójcik N, Sielicki P, Bielewicz M, Grodzki T PMID: 31708987 [PubMed]
Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
Should hepatitis C-infected kidneys be transplanted into uninfected recipients as standard practice? This editorial explores the issues.American Journal of Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Transplantation Journal Article Source Type: news
ConclusionsGlecaprevir/pibrentasvir was highly efficacious and well tolerated in HCV treatment-na ïve patients with APRI ≤ 1 and no prior evidence of cirrhosis.Trial RegistrationClinicalTrials.gov number, NCT03212521.FundingAbbVie.Plain Language SummaryPlain language summary available for this article.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
This study highlights a limited uptake of HCV treatment among MMT patients, and a need to strengthen the popularity of DOT and DAAs and integrate them into Chinese MMT clinics.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusions: Vitamin D supplement did not increase SVR in treatment naïve patients with CHC irrespective of genotype. PMID: 31710801 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
Canadian researchers found giving uninfected recipients a combination of antiviral and cholesterol-lowering drugs prevented them from contracting the virus.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Condition:   HCV Infection Interventions:   Device: Optical coherence tomography angiography;   Drug: Sofosbuvir (Sovaldi) Sponsor:   Mohamed Saad Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Human pegivirus (HPgV) is structurally similar to hepatitis C virus (HCV) and was discovered 20 years ago. Its distribution, natural history and exact rule of this viral group in human hosts remain unclear. Ou...
Source: Virology Journal - Category: Virology Authors: Tags: Case Report Source Type: research
Liliana Chemello Direct antiviral agents (DAAs) have excellent efficacy against chronic hepatitis C virus (HCV) infection. Despite this strength, recent studies raised concerns about an unexpected hepatocellular carcinoma (HCC) occurrence rate after DAA therapy. In this exploratory case-control study, we evaluated the potential use of miRNAs as serum biomarkers for the detection of early HCC in DAA-treated patients. In the discovery phase, the circulating miRNome was assessed in 10 matched patients with (HCC+) or without HCC (HCC−) occurrence. Microarray analysis was performed before (T0) and after one month...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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