Zika - The road from an obscure disease to an epidemic of information

Source: Revista da Sociedade Brasileira de Medicina Tropical - Category: Tropical Medicine Source Type: research

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This study describes the efforts and outcomes associated with the establishment of a clinical sample repository during the 2016 Zika virus epidemic. To overcome the challenge of limited access to clinical samples to support diagnostic test development, multiple US Department of Health and Human Services (HHS) agencies formed a partnership to create the HHS Zika Specimen Repository. In 2016-2017, the Biomedical Advanced Research and Development Authority and the Centers for Disease Control and Prevention collected patient specimens (4420 convalescent sera aliquots from 100 donors and 7171 plasma aliquots from 239 donors), c...
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
th Du Chen Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome, which includes microcephaly and other neurological malformations. No therapeutic agents have, so far, been approved for the treatment of ZIKV infection in humans; as such, there is a need for a continuous effort to develop effective and safe antiviral drugs to treat ZIKV-caused diseases. After screening a natural product library, we have herein identified four natural products with anti-ZIKV activity in Vero E6 cells, including gossypol, curcumin, digitonin, and conessine. Except for curcumin, the other three natura...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
AbstractThe rate of evolution of viral genomes is a fundamental parameter for understanding the origin and spread of epidemics. For instance, molecular dating is one of the many practical outcomes of evolutionary rate estimation. In this sense, the rate of evolution of ZIKV merits attention, because it has been shown to be higher than the average rate reported for other flaviviruses. It has been hypothesized that the higher rate of ZIKV evolution is due to a bias related to the analysis of sequences collected within a short time range, which would increase the chance of sampling slightly deleterious nucleotide polymorphism...
Source: Archives of Virology - Category: Virology Source Type: research
New emerging and reemerging infectious disease outbreaks have continued to cause much human suffering and loss of life worldwide. During the past 2 decades, several landmark events in the field of infectious diseases with epidemic potential have occurred. The SARS (severe acute respiratory syndrome) pandemic (2002 –2004), the Ebola virus disease (EVD) outbreak in West Africa (2013–2016), the cholera outbreak in Yemen (2015–2018), the Zika virus in the Americas and southeast Asia (2016–2018), Lassa fever (LF) in Nigeria (2018), diphtheria in Venezuela (2016-2017) and in Yemen (2017-2018), Yellow feve...
Source: Infectious Diseases Clinics of North America - Category: Infectious Diseases Authors: Tags: Preface Source Type: research
Aedes aegypti is the main vector of three neglected tropical diseases: dengue, zika and chikungunya. Dengue is under surveillance by health organizations worldwide due to the risk of epidemics. Since there is no specific treatment for dengue, most studies have focused on preventing the reproduction and/or development of the mosquitoes. We studied the larvicidal activity of five phosphates and phosphorothioates derived from cardol, one of the four main components of cashew nut shell liquid (Anacardium occidentale L.), at different concentrations. The organophosphorothioate derivatives were tested for their in vitro inhibito...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
Epidemics of dengue, chikungunya and Zika are a growing threat to areas where Aedes aegypti are present. The efficacy of chemical control of Ae. aegypti is threatened by the increasing frequency of insecticide re...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
CONCLUSIONS: Children are especially vulnerable to this group of diseases due to characteristics that facilitate the development of the most severe forms. More detailed knowledge of this group of diseases allows the pediatrician to diagnose them earlier, implement the correct treatment, monitor warning signs for the most severe forms, and establish effective preventive measures. PMID: 31605670 [PubMed - as supplied by publisher]
Source: Jornal de Pediatria - Category: Pediatrics Authors: Tags: J Pediatr (Rio J) Source Type: research
By Ifeanyi NsoforABUJA, Oct 7 2019 (IPS) As a Public Health Doctor, I often meet people who experience stigma simply because they live with HIV. One person who still haunts me is a woman who is HIV positive and when she was in labor, a midwife would not help her. Instead she shouted at her to just push out the baby and then she stood far away from the bedside, disgusted by the woman’s HIV status.  No one should go through such stigma at a vulnerable situation when they are about to birth life. Another lady I met was denied university admission because she is HIV positive. She was screened for HIV without h...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health HIV/AIDS Source Type: news
by Ricardo Arraes de Alencar Ximenes, Dem ócrito de Barros Miranda-Filho, Elizabeth B. Brickley, Ulisses Ramos Montarroyos, Celina Maria Turchi Martelli, Thalia Velho Barreto de Araújo, Laura C. Rodrigues, Maria de Fatima Pessoa Militão de Albuquerque, Wayner Vieira de Souza, Priscila Mayrelle da Silva Castanha, Rafael F. O. França, Raf ael Dhália, Ernesto T. A. Marques, on behalf of the Microcephaly Epidemic Research Group (MERG) Defining cases of Zika virus (ZIKV) infection is a critical challenge for epidemiological research. Due to ZIKV’s overlapping clinical features and poten...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
[Variations in the detection of congenital Zika syndrome associated with changes in protocolsVariación de la detección del síndrome congénito por el virus del Zika en función de los cambios de los protocolos]. Rev Panam Salud Publica. 2019;43:e79 Authors: Mocelin HJS, do Prado TN, Freitas PSS, Bertolde AI, Perez F, Riley LW, Maciel ELN Abstract In 2015, Brazil faced a Zika virus epidemic that spread to other countries in the world. As a result, recommendations regarding reporting criteria for congenital Zika syndrome (CZS) were issued in the form of protocols. The fre...
Source: Pan American Journal of Public Health - Category: International Medicine & Public Health Tags: Rev Panam Salud Publica Source Type: research
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