Special Issue Review The cancer epigenome: Concepts, challenges, and therapeutic opportunities

Cancer biology is profoundly influenced by changes in the epigenome. Because the dynamic plasticity of the epigenome lends itself well to therapeutic manipulation, the past few years have witnessed an unprecedented investment in the development, characterization, and translation of targeted epigenetic therapies. In this review, I provide a broad context for recent developments that offer a greater understanding of how epigenetic regulators facilitate the initiation, maintenance, and evolution of cancer. I discuss newly developed epigenetic therapies and the cellular and molecular mechanisms that may govern sensitivity and resistance to these agents. I also review the rationale for future combination therapies involving existing and emerging epigenetic drugs. Author: Mark A. Dawson
Source: ScienceNOW - Category: Science Authors: Tags: Frontiers in Cancer Therapy Source Type: news

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Publication date: Available online 20 September 2018Source: CellAuthor(s): Larissa D. Cunha, Mao Yang, Robert Carter, Clifford Guy, Lacie Harris, Jeremy C. Crawford, Giovanni Quarato, Emilio Boada-Romero, Halime Kalkavan, Michael D.L. Johnson, Sivaraman Natarajan, Meghan E. Turnis, David Finkelstein, Joseph T. Opferman, Charles Gawad, Douglas R. GreenSummaryTargeting autophagy in cancer cells and in the tumor microenvironment are current goals of cancer therapy. However, components of canonical autophagy play roles in other biological processes, adding complexity to this goal. One such alternative function of autophagy pro...
Source: Cell - Category: Cytology Source Type: research
ConclusionsNeither patient nor physician race was significantly associated with risk estimation or surgical recommendations. These findings do not provide an explanation for documented racial disparities in lung cancer therapy. Further investigation is needed to identify the mechanism underlying these disparities.Visual Abstract
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
This study tested>3,800 drugs in high-throughput fashion and found that retinoic acid, best known as an acne treatment, may be effective for adenoid cystic carcinoma. A clinical trial is now being planned at the Dana-Farber Cancer Institute.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Professor Judi Fouladbakhsh speaks withCancer Network about evidence-based holistic approaches to cancer care.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Detection and capture of circulating tumor cells (CTCs) with microfluidic chips hold significance in cancer prognosis, diagnosis, and anti-cancer treatment. The counting of CTCs provides potential tools to evaluate cancer stages as well as treatment progress. However, facing the challenge of rareness in blood, the precise enumeration of CTCs is challenging. In the present research, we designed an inertial-deformability hybrid microfluidic chip using a long spiral channel with trapezoid-circular pillars and a capture zone. To clinically validate the device, the microfluidic chip has been tested for the whole blood and lysed...
Source: Journal of Medical Devices, Transactions of the ASME - Category: Medical Devices Source Type: research
Jakob von Frieling, Christine Fink, Jacob Hamm, Kenneth Klischies, Michael Forster, Thomas C. G. Bosch, Thomas Roeder, Philip Rosenstiel, Felix Sommer
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 20 September 2018Source: Results in PhysicsAuthor(s): Limin Dong, Dongyue Liu, Xuejiao Li, Kejia Wu, Wanqi ZhangAbstractBiomass carbon quantum dots (CQDs) were widely used in bioimaging and WO2.72 has great potential in cancer therapy. The biomass CQDs were prepared by mixed acid oxidation method with biomass materials such as pods, tobacco leaves and cysteine as carbon sources. Properties of biomass carbon quantum dots were characterized, including micromorphology, the functional group composition, photoluminescence properties and fluorescence labeling ability in HepG2 cells. And the cyt...
Source: Results in Physics - Category: Physics Source Type: research
Authors: Zhang D, Dong Y, Zhao Y, Zhou C, Qian Y, Hegde ML, Wang H, Han S Abstract The use of plant‑based compounds derived from traditional medicine to improve human diseases has been gaining momentum, due to their high bioavailability and moderate adverse effects. Sinomenine is one such biomonomer alkali compound derived from Sinomenium acutum and is known for its anti‑inflammatory and antitumor effects. However, the molecular mechanism(s) of its antitumor properties are not fully characterized. In the present study, we evaluated the radiosensitizing effects of the water‑soluble sinomenine, sinomenine hydro...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Lopes-Souza P, Dionello CF, Sá-Caputo DDC, Moreira-Marconi E, Frederico EHFF, Marchon RM, Bergmann A, Furness T, Bernardo-Filho M Abstract The purpose of this systematic review was to investigate the effects of whole body vibration (WBV) exercise in the management of cancer therapy-related morbidities. The PubMED and PEDro databases were used to access publications published in English about the use of whole body vibration (WBV) exercises in cancer patients until February 22nd 2017. The studies included were classified according to the level of evidence (LE) by the National Health and Medical Resear...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
International Journal of Dermatology, EarlyView.
Source: International Journal of Dermatology - Category: Dermatology Authors: Source Type: research
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