Gum Arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial

AbstractBackgroundSickle cell anemia patients suffer from oxidative stress due to chronic inflammation and self-oxidation of sickle hemoglobin (Hb S). Chronic oxidative stress contributes to endothelial dysfunction, inflammation and multiple organ damage in sickle cell disease (SCD). Thus, antioxidant medication may favorably influence the disease. Gum Arabic (GA), edible, dried, gummy exudates from Acacia Senegal tree, has been claimed to act as an anti-oxidant and cytoprotective agent, protecting against experimental hepatic, renal and cardiac toxicities in rats. We hypothesized that regular intake of GA increases anti-oxidant capacity and reduce oxidative stress.MethodsForty-seven patients (5 –42 years) carrying hemoglobin SS were recruited. Patients received 30 g/day GA for 12 weeks. Total anti-oxidant capacity (TAC), malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels were measured by spectrophotometric methods before and after GA intake. Complete blood count was measured by sysmex.ResultsGum Arabic significantly increased TAC levelP 
Source: BMC Hematology - Category: Hematology Source Type: research

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Sickle cell anemia, the most common form of sickle cell disease (SCD) is caused by the homozygous mutation in the β-globin gene, which leads to erythrocyte sickling, impaired rheology, vaso-occlusion and premature hemolysis6. Vaso-occlusion and hemolysis are the two predominant pathophysiological events in SCD that contribute to chronic organ damage and acute systemic painful vaso-occlusive episode (VOE)3,6. E arlier, we have shown that VOE involves entrapment of large neutrophil-platelet aggregates in lung arterioles of SCD mice, which is inhibited following IV administration of P-selectin function blocking antibody5.
Source: Experimental Hematology - Category: Hematology Authors: Tags: Brief Communication Source Type: research
We present a new method to obtain erythrocyte shape classification using peripheral blood smear sample images. The aim of the method is to segment the cells, to separate clusters and classify cells (circulars, elongated and others). We compared our method with state-of the-art. Results showed that our method with is superior for the diagnosis support of sickle cell anemia.
Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
Newly developed measures of health care quality for children with sickle cell anemia (SCA) have revealed significant performance gaps in recommended care. Historically, health systems, Medicaid health plans, and state Medicaid programs have not partnered with patients and families to improve SCA care delivery. We organized 2 novel multistakeholder design meetings to identify potential interventions to deliver high-quality preventive care for children with SCA. Invitees included patients with SCA, families, and representatives from pediatric hematology clinics, Medicaid health plans, community organizations, and a state Med...
Source: Journal of Pediatric Hematology Oncology - Category: Hematology Tags: Online Articles: Original Articles Source Type: research
Abstract Malaria etiologies with pathophysiological similarities to hypertension currently constitute a major subject of research. The malaria-high blood pressure hypothesis is strongly supported by observations of the increasing incidence of hypertension in malaria-endemic, low and middle-income countries (LMICs) with poor socio-economic conditions, particularly in sub-Saharan African countries. Malnutrition and low birth weight with persistent symptomatic malaria presentations in pregnancy correlate strongly with the development of preeclampsia, gestational hypertension and subsequent hypertension in adult life....
Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research
Abstract Sickle cell hemoglobin (HbS) is an example of a genetic variant of human hemoglobin where a point mutation in the β globin gene results in substitution of glutamic acid to valine at sixth position of the β globin chain. Association between tetrameric hemoglobin molecules through noncovalent interactions between side chain residue of βVal6 and hydrophobic grooves formed by βAla70, βPhe85 and βLeu88 amino acid residues of another tetramer followed by the precipitation of the elongated polymer leads to the formation of sickle-shaped RBCs in the deoxygenated state of HbS. There a...
Source: Sub-Cellular Biochemistry - Category: Biochemistry Authors: Tags: Subcell Biochem Source Type: research
Abstract During the past two decades, significant advances have been made in our understanding of the human fetal and embryonic hemoglobins made possible by the availability of pure, highly characterized materials and novel methods, e.g., nano gel filtration, to study their properties and to correct some misconceptions. For example, whereas the structures of the human adult, fetal, and embryonic hemoglobins are very similar, it has generally been assumed that functional differences between them are due to primary sequence effects. However, more recent studies indicate that the strengths of the interactions between...
Source: Sub-Cellular Biochemistry - Category: Biochemistry Authors: Tags: Subcell Biochem Source Type: research
CSF xanthochromia by spectroscopy should not be dismissed in the context of hyperbilirubinemia in a patient with sickle cell anemia. Xanthochromia detected by spectrophotometry offers a vital clue that further invasive diagnosis is required. AbstractCSF (Cerebrospinal Fluid) xanthochromia by spectroscopy should not be dismissed in the context of hyperbilirubinemia in a patient with sickle cell anemia. Xanthochromia detected by spectrophotometry offers a vital clue that further invasive diagnosis is required.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates ...
Source: BMC Research Notes - Category: Research Authors: Tags: Research note Source Type: research
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Source: Journal of Clinical Periodontology - Category: Dentistry Authors: Tags: J Clin Periodontol Source Type: research
CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases. However, these genetic screens are limited in scope: They can only edit or target DNA. For many regions of the human genome, targeting DNA may not be effective, and other organisms, such as RNA viruses like coronavirus or flu, cannot be targeted at all with existing DNA-targeting CRISPR screens.
Source: World Pharma News - Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
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