Thyroid V40 Predicts Primary Hypothyroidism Following Intensity Modulated Radiotherapy for Nasopharyngeal Carcinoma

Primary hypothyroidism (HT) is a common occurrence after intensity modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC). This is a study to investigate the various clinical and thyroid dosimetric parameters that could predict the risk of primary hypothyroidism after IMRT and to determine useful thyroid dose constraints to guide radiotherapy planning. Thyroid V40 is predictive of primary hypothyroidism following intensity modulated radiotherapy for nasopharyngeal carcinoma and V40 ≤85% can be a useful dose constraint to adopt during IMRT planning without compromising tumor coverage.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research