Variability of Zaleplon 5-Oxidase Activity in Mice and Humans, and Inhibition by Raloxifene

Conclusion: High inter-individual variability of ZAL 5-oxidase activity and potential for interaction of ZAL with other medicines that are inhibitors of aldehyde oxidase should be taken into consideration in clinical usage of ZAL.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research