Different genetic alteration of A20 in a S ézary syndrome case with Vα2‐Jα22 T cell clone

ConclusionsThe genetic alteration of A20 in the SS case was different from the T‐ALL samples and similar to the cases with refractory autoimmune disease and related to tumorigenesis. The findings lead to discuss whether such SNPs of A20 may link the refractory autoimmune inflammation and the tumorigenesis.
Source: Asia-Pacific Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Original article Source Type: research

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Publication date: Available online 18 November 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Zhen Wang, Hui Gyu Park, Dong Hao Wang, Riki Kitano, Kumar S.D. Kothapalli, J. Thomas BrennaAbstractBranched chain fatty acids (BCFA) and linear chain/normal odd chain fatty acids (n-OCFA) are major fatty acids in human skin lipids, especially sebaceous gland (SG) wax esters. Skin lipids contain variable amounts of monounsaturated BCFA and n-OCFA, in some reports exceeding over 20% of total fatty acids. Fatty acid desaturase 2 (FADS2) codes for a multifunctional enzyme that catalyz...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - Category: Lipidology Source Type: research
This study evaluated outcomes associated with treatment strategies for this nonagenarian population.MethodsTreatment and overall survival for patients 90 years and older with NSCLC in the National Cancer Data Base (2004-2014) were evaluated using logistic regression, the Kaplan-Meier method, and multivariable Cox proportional hazard models.ResultsThe majority (n = 4152, 57.6%) of the 7205 patients 90 years or older with stage I-IV NSCLC did not receive any therapy. For the entire cohort, receiving treatment was associated with significantly better survival when compared with no therapy (5-year survival, 9.3% [95% confidenc...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsThe delay in surgical resection of StageIIIa NSCLC is not associated increased early mortality, however it is associated with worse 3-year post-resection survival.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Canadian Journal of Zoology, e-First Articles. Recent studies have noted the differential effects of marine versus terrestrial diets on the carbon and nitrogen stable isotope (13C and 15N, respectively) diet-to-tissue discrimination values and incorporation rates for omnivorous and carnivorous mammals. Inaccurate estimates of these parameters may result in misrepresentation of diet composition or in the timing of diet shifts. Here, we present the results of a diet-switch experiment designed to estimate diet-to-tissue discrimination values and incorporation rates for tissues of gray wolves (Canis lupus Linnaeus, 1758) fed a...
Source: Canadian Journal of Zoology - Category: Zoology Authors: Source Type: research
A highly engineered anti-CD20 antibody, obinutuzumab, enhances renal responses in lupus nephritis compared with standard immunotherapy and is well tolerated. A Phase 3 study is planned for 2020.Medscape Medical News
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Nephrology News Source Type: news
In conclusion, data presented in the current study suggest that tobacco smoking might cause alveolar tissue inflammation and vascular injury causing an immune response that elevates the white blood cells count. Another suggestion is that tobacco smoking defects the pulmonary gaseous exchange mechanism leading to the secondary polycythemia indicated by the increase in red blood cell count, hemoglobin levels, hematocrit and by the low serum erythropoietin levels.
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
In this study, we report that the dietary isoflavone genistein (GN) synergistically improved antineoplasticity of CC in breast cancer by arresting cells at G2/M phase culminating in ROS dependent apoptosis. The combination of CC plus GN caused dysregulation of Bax and Bcl-2 ratio inducing mitochondrial dysfunction, activation of Caspase-3/7, -9 and PARP cleavage. Further, combination significantly suppresses phosphorylation of PI3K/Akt/NF-κB, enhancing apoptosis. Additionally, combination markedly reduced tumor growth compared to CC and GN alone in mouse 4T1 breast tumor model.SignificanceTogether, these studies sugg...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 18 November 2019Source: Life SciencesAuthor(s): Kosar Babaei, Shima Shams, Arman Keymoradzadeh, Sogand Vahidi, Parisa Hamami, Roya Khaksar, Seyedeh Elham Norollahi, Ali Akbar SamadaniAbstractImportance of dysregulation and expression of microRNAs (miRNAs) has been confiemed in many disorders comprising cancer. In this way, different approaches to induce reprogramming from one cell type to another in oerder to control the cell normal mechanisem, comprising microRNAs, combinatorial small molecules, exosome-mediated reprogramming, embryonic microenvironment and also lineage-specific transcri...
Source: Life Sciences - Category: Biology Source Type: research
Conclusions: Many of the techniques introduced those years are still in use. PMID: 31738660 [PubMed - as supplied by publisher]
Source: Acta Chirurgica Belgica - Category: Surgery Tags: Acta Chir Belg Source Type: research
Publication date: Available online 18 November 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Juan Liao, Siyu Peng, Mei Long, Yaya Zhang, Huaming Yang, Yi Zhang, Jing HuangAbstractNatural halloysite clay nanotubes (halloysite nanotubes, HNTs) are potentially used in colon cancer therapy owing to their excellent physicochemical properties. However, the size-dependent interaction between HNTs and colon cancer cells is still an unresolved challenge. Herein, we analyzed the interfacial interactions between HNTs and colon cancer cells, and evaluated the size-dependent biological effects o...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
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