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The evidence base for Hormone Replacement Therapy (HRT): what can we believe?

The'facts'that most women and clinicians consider in making the decision to use, or not use, HRT are frequently wrong or incorrectly applied according to a professor. New research raises serious questions about the'facts'that have led women and their doctors to believe hormone therapy (often called HRT) is unsafe.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Abstract Background/AimTo evaluate and stratify early cardiovascular risk of transsexuals who underwent pharmacological and/or surgical gender reassignment. MethodsFifty‐six transsexuals were divided into two groups: group 1 – underwent gonadectomy (orchiectomy for transwomen and hystero‐annessiectomy for transmen); group 2 – hormone replacement therapy alone. All participants underwent carotid artery intima‐media thickness (C‐IMT) and flow‐mediated vasodilation (FMD) of brachial artery evaluations. ResultsFMD was lower in patients who had undergone gonadectomy compared with non‐surgically treated p...
Source: Internal Medicine Journal - Category: Internal Medicine Authors: Tags: Original Article Source Type: research
ConclusionsMore than 50% in the total cohort had hormone replacement. Although adherence was generally good, this study shows that hormone replacement therapy may be improved. This may be achieved by better individualization of the treatment and by providing specific information to patients regarding both long term and short‐term hormonal effects and side effects.This article is protected by copyright. All rights reserved.
Source: Clinical Endocrinology - Category: Endocrinology Authors: Tags: Original Article Source Type: research
Authors: Gambacciani M, Biglia N, Cagnacci A, DI Carlo C, Caruso S, Cicinelli E, DE Leo V, Farris M, Gambera A, Guaschino S, Lanzone A, Paoletti AM, Russo N, Vicariotto F, Villa P, Volpe A Abstract In the last decade the risk benefits ratio of HRT has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausel Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause Society,...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
CONCLUSION: Until additional studies are performed, the risks and benefits must be weighed on an individual basis with consideration of prophylaxis when a decision is made to continue these medications in the perioperative period. Part of this decision making includes the risk of fetal harm in an unwanted pregnancy in preparation for nonobstetric surgery versus an increased risk of venous thromboembolism. PMID: 28969534 [PubMed - as supplied by publisher]
Source: Current Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Clin Pharmacol Source Type: research
It’s not going to kill you to take hormone replacement therapy. That’s the take home message from the latest analysis of the Women’s Health Initiative, the largest and longest randomized trial of hormone replacement therapy (HRT) in menopausal women. After almost 18 years of follow up in the WHI, there was no increase in overall mortality, including death rates from cancer, in women taking HRT for up to 5.6 years (estrogen plus progestin) or 7.2 years (estrogen alone). There was a non-significant reduction in mortality among those who started HRT between ages 50 and 59, the group most likely to ...
Source: The Blog That Ate Manhattan - Category: Primary Care Authors: Tags: Hormone Replacement Menopause WHI breast cancer estrogen HRT Prempro Source Type: blogs
CONCLUSIONS: A small single trial contributed evidence of moderate quality that the use of growth hormone for a year may improve height velocity of children with thalassaemia although height SD score in the treatment group was similar to the control group. There are no randomised controlled trials in adults or trials that address the use of growth hormone therapy over a longer period and assess its effect on final height and quality of life. The optimal dosage of growth hormone and the ideal time to start this therapy remain uncertain. Large well-designed randomised controlled trials over a longer period with sufficient du...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
According to a study published inJAMA, women who take hormone replacement therapy may be no more likely to die prematurely than women who do not take hormones.Reuters 
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
For decades now, women navigating menopause have been buffeted by shifting research findings on the risks and possible benefits of hormone-replacement therapy. Now, a landmark clinical trial that followed more than 27,000 subjects for roughly 18 years has offered some conclusive evidence that neither...
Source: Los Angeles Times - Science - Category: Science Authors: Source Type: news
(Reuters Health) - Women who take hormone replacement therapy (HRT) to ease menopause symptoms like hot flashes and night sweats may be no more likely to die prematurely than women who don ’t take hormones, a new study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
The pendulum has swung from one extreme to the other when it comes to hormone replacement therapy (HRT) to treat symptoms of menopause. At first, the replacement hormones—mostly a combination of estrogen and progestin to replace what the body stops making after menopause—were seen as a panacea. Doctors thought they could not only relieve hot flashes and night sweats, but also prevent chronic aging diseases like heart problems and weakening bones. But studies then found that the supplement hormones could lead to a higher risk of breast cancer—and that they didn’t protect the heart after all. In the l...
Source: TIME.com: Top Science and Health Stories - Category: Consumer Health News Authors: Tags: Uncategorized Drugs estrogen Hormone Therapy hormones for menopause hot flashes night sweats progestin Reproductive Health treating menopause Source Type: news
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