Old-Style Chemo Is Still A Mainstay In The Age Of Targeted Cancer Therapy

Scientists hunting cures for cancer hope to find targeted therapies with fewer side effects. But there's also new evidence that old-style chemo sometimes helps gentler treatments work better.(Image credit: UIG Platinum/UIG via Getty Images)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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Publication date: 18 October 2018Source: Cell, Volume 175, Issue 3Author(s): Kaiwei Liang, Edwin R. Smith, Yuki Aoi, Kristen L. Stoltz, Hiroaki Katagi, Ashley R. Woodfin, Emily J. Rendleman, Stacy A. Marshall, David C. Murray, Lu Wang, Patrick A. Ozark, Rama K. Mishra, Rintaro Hashizume, Gary E. Schiltz, Ali ShilatifardSummaryThe super elongation complex (SEC) is required for robust and productive transcription through release of RNA polymerase II (Pol II) with its P-TEFb module and promoting transcriptional processivity with its ELL2 subunit. Malfunction of SEC contributes to multiple human diseases including cancer. Here...
Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 18 October 2018Source: CellAuthor(s): Matthew M. Gubin, Ekaterina Esaulova, Jeffrey P. Ward, Olga N. Malkova, Daniele Runci, Pamela Wong, Takuro Noguchi, Cora D. Arthur, Wei Meng, Elise Alspach, Ruan F.V. Medrano, Catrina Fronick, Michael Fehlings, Evan W. Newell, Robert S. Fulton, Kathleen C.F. Sheehan, Stephen T. Oh, Robert D. Schreiber, Maxim N. ArtyomovSummaryAlthough current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment. Here, using complementary forms of high-dimensional profiling, we define d...
Source: Cell - Category: Cytology Source Type: research
This study examined the role of H2S in drug resistance in liver cancer cells.Materials and methodsHuman primary hepatocellular carcinoma cell line (HepG2) and doxorubicin (Dox)-resistant cells were used in this study. Cell survival was analyzed by MTT, Annexin V-FITC/propidium iodide staining and clonogenic assay. Western blotting was used for analysis of protein expression, and immunoprecipitation was used to determine interactions of LXR/RXR.Key findingsThe expression of H2S-generating enzyme cystathionine gamma-lyase (CSE) was inhibited by doxorubicin treatment in HepG2 cells, and H2S sensitized Dox-inhibited cell survi...
Source: Life Sciences - Category: Biology Source Type: research
Treatment for prostate cancer with external beam radiotherapy was found to be associated with an increased risk for development of bladder cancer when compared with radical prostatectomy.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Publication date: November 2018Source: Chinese Chemical Letters, Volume 29, Issue 11Author(s): Yuzhen Wang, Yujun Song, Guixian Zhu, Dechen Zhang, Xuewu LiuAbstractMore recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibili...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Gadodiamide (Gd-DTPA-BMA) is a gadolinium (Gd) chelate composed of two carboxylate groups of diethylenetriaminepentaacetic acid (DTPA) and two amide groups (BMA). Gd complexes are the most widely used contrast agents in nuclear magnetic resonance. Furthermore, our research group has demonstrated the potential of liposomes containing Gd-DTPA-BMA for cancer therapy. The aim of this study was to develop and validate a chemometric-assisted method by hydrophilic interaction liquid chromatography (HILIC) for determination of Gd-DTPA-BMA in liposomes. The chromatographic conditions obtained were: Sequant ® ZIC®-HILIC Merc...
Source: Journal of the Brazilian Chemical Society - Category: Chemistry Source Type: research
During cancer progression, tumor cells interact with the neighboring environment, including neuronal tissue. The important influence of the nervous system on growth and metastasis of cancer is now widely accepted. As such, using medications that traditionally target the nervous system may be an avenue toward treating cancer. The focus of this review is to detail how several classes of medications, traditionally used to treat nervous system disorders, impact cancer. Specifically, we review the preclinical and clinical evidence that support the use of anti-β-adrenergic, anticholinergic, antipsychotic, and antidepressant...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: REVIEW ARTICLE Source Type: research
Publication date: Available online 16 October 2018Source: International Journal of PharmaceuticsAuthor(s): Kensuke Yotsumoto, Kenta Ishii, Miho Kokubo, Sakiko YasuokaAbstractPolymeric micelles, which form through the self-assembly of poly(ethylene glycol)–poly(amino acid) block copolymers, are systemic nanocarriers in targeted cancer therapy. These micelles can encapsulate therapeutic compounds, such as lipophilic substances, charged compounds, and metal complexes, that have characteristics of increased solubility, sustained release, and improved tissue distribution. However, few studies have been conducted on the lo...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
ACS NanoDOI: 10.1021/acsnano.8b07079
Source: ACS Nano - Category: Nanotechnology Authors: Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.8b08243
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
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