Old-Style Chemo Is Still A Mainstay In The Age Of Targeted Cancer Therapy

Scientists hunting cures for cancer hope to find targeted therapies with fewer side effects. But there's also new evidence that old-style chemo sometimes helps gentler treatments work better.(Image credit: UIG Platinum/UIG via Getty Images)
Source: NPR Health and Science - Category: Consumer Health News Authors: Source Type: news

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Qingxin Mu, Bing Yan
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Almost everyone experiences bad breath once in a while. But for some people, bad breath is a daily problem, and they struggle to find a solution. Approximately 30% of the population complains of some sort of bad breath. Halitosis (Latin for “bad breath”) often occurs after a garlicky meal or in the morning after waking. Other causes of temporary halitosis include some beverages (including alcoholic drinks or coffee) and tobacco smoking. Some people may not be aware of their own halitosis and learn about it from a relative, friend, or coworker, causing some degree of discomfort and distress. In severe cases, bad...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Dental Health Source Type: blogs
AbstractBreast cancer has developed to become the leading type of cancer in females. For this study, 80 women were examined after chemotherapy for breast cancer and compared to 80 healthy age-matched women. This cross-sectional study comprised a dental examination with number of teeth, caries frequency (DMFT) and the presence of periodontal diseases (PSI). With the help of X-rays (OPG), the number of root canal fillings and apical lesions (LEO/LPO) were recorded. Furthermore, the education level, body mass index (BMI), smoking habits and general health conditions were recorded. All women completed questionnaires on oral he...
Source: Odontology - Category: Dentistry Source Type: research
Publication date: Available online 18 January 2019Source: Materials Science and Engineering: CAuthor(s): Dnyaneshwar Kalyane, Nidhi Raval, Rahul Maheshwari, Vishakha Tambe, Kiran Kalia, Rakesh K. TekadeAbstractIn tumorous tissues, the absence of vasculature supportive tissues intimates the formation of leaky vessels and pores (100 nm to 2 μm in diameter) and the poor lymphatic system offers great opportunity to treat cancer and the phenomenon is known as Enhanced permeability and retention (EPR) effect. The trends in treating cancer by making use of EPR effect is increasing day by day and generate multitudes of poss...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
The physical and psychological side effects of breast cancer therapies can have substantial impact on survivors' physical and social functioning. Roughly half of the more than 3 million Americans alive with a history of breast cancer report adverse, function-degrading sequelae related to their oncologic treatments. Care delivery models for the timely delivery of rehabilitation services have been proposed yet limitedly vetted or implemented. These include the prospective surveillance model, procedure-linked referrals, survivorship care plans, and risk stratification. Patients' capacity to engage in the rehabilitative proces...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Literature Review Source Type: research
CONCLUSIONS TCL-based immunotherapy has discrepant anti-tumor efficiency in different TNBC cell lines by PDL-1/PD interaction, providing the theoretical basis of TCL-based immunotherapy in TNBC. PMID: 30653481 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
by Craig Klugman, Ph.D. Jump to The Resident (Season 2; Episode 10): What would you do doctor?a>;Jump to The Good Doctor (Season 1; Episode 11): Ignoring patient rights; unnecessary risks; crisis planning; Jump to New Amsterdam (Season 1; Episode 11): Superutilizers and racism; Jump to Chicago Med (Season 4; Episode 11): Triage, gestational surrogacy conflicts; ends justifies the means The Resident (Season 2; Episode 10): What would you do doctor? As Hunter is released from prison on murder charges for killing patients with unneeded cancer therapy (sometimes on people without cancer), one of her victims is in the ED wit...
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: BioethicsTV Conflict of Interest Decision making End of Life Care Featured Posts Informed Consent professional ethics Public Health Reproductive Ethics Source Type: blogs
tti E Abstract Noncoding RNAs play important regulatory roles in diverse biological processes and their misregulation might lead to different diseases, including cancer. Previous studies have reported the evolving role of miRNAs as new potential biomarkers in cancer diagnosis, prognosis, as well as predictive biomarkers of chemotherapy response or therapeutic targets. In this review, we outline the involvement of noncoding RNA in pancreatic cancer, providing an overview of known miRNAs in its diagnosis, prognosis and chemoresistance. In addition, we discuss the influence of non-coding RNAs in the metastatic behavi...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Abstract Apoptosis is a vital physiological process, which is observed in various biological events. The anti-apoptotic and pro-apoptotic members of Bcl-2 family are the most characterized proteins which are involved in the regulation of apoptotic cell death. The anti-apoptotic proteins such as Bcl-2 and Bcl-xL prevent apoptosis,whereas pro-apoptotic members like Bax and Bak, elicit the release of caspases from death antagonists inducing apoptosis. Thus, the Bcl-2 family of proteins play a vital role in controlling programmed cell death. Over expression of anti-apoptotic Bcl-2 proteins are often directly associate...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
In this study, hyaluronic acid (HA) conjugated bovine serum albumin (BSA) nanoparticles have been synthesized according to AmiNoAcid Decorated and Light Underpinning Conjugation Approach (ANADOLUCA) that provides microemulsion polymerization at room temperature, under a nitrogen atmosphere in daylight. The synthesized nano BSA-HA particles have been characterized by Circular Dichroism (CD), Scanning Electron Microscopy (SEM), fluorescence spectrum and thermal gravimetric analysis. Then, nano BSA-HA particles have been used in vitro cytotoxicity analysis and imaging of PANC-1 ATCC® CRL146 cells. Cytotoxic effect of nano...
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research
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