Women's Wellness: Finding treatments to fight fibroids

Uterine fibroids?are noncancerous tumors of the uterus that often appear during childbearing years. They commonly cause heavy menstrual bleeding, pelvic pain and pressure, bowel and bladder problems, and sometimes, infertility and miscarriage. Fibroids are also the leading cause of hysterectomy. However, there are two treatments that can sometimes be considered before a decision is made [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news

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Uterine fibroids are benign monoclonal neoplasms of the myometrium that represent the most common tumor in reproductive-age women worldwide. Their prevalence is approximately 70% –80% in women by the age of 50 years. Histopathology analysis shows increased smooth muscle cells, collagen, proteoglycans, and fibronectin in a disorganized matter (1). This abnormal proliferation causes anatomic distortion leading to the signs and symptoms present in uterine fibroids, which inc lude abnormal uterine bleeding, pelvic pain, and reproductive dysfunction (impaired implantation, infertility, and spontaneous abortion).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Uterine fibroids (UFs; leiomyomas) are benign monoclonal neoplasms of the myometrium and represent the most common tumors in reproductive-age women worldwide. Tumors occur in approximately 77% of women overall and are clinically manifest in approximately 25% by age 45  years. Although benign, these tumors are nonetheless associated with significant morbidity; they are the primary indication for hysterectomy and a major source of gynecologic and reproductive dysfunction, ranging from profuse menstrual bleeding and pelvic pain to infertility, recurrent miscarriage , and preterm labor.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
The objective of this study was to demonstrate a markedly enlarged isthmocele, that resulted in the miscarriage of a 12-week IVF twin pregnancy.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Source Type: research
​BY GREGORY TAYLOR, DO, &JACKLYN MCPARLANE​, DOA 31-year-old woman with a significant medical history for one ectopic pregnancy and five spontaneous abortions presented with abdominal pain and vaginal bleeding. Her symptoms started abruptly two days earlier, and the pain was located in the right lower quadrant, which had become diffuse and she described as sharp. She was also experiencing nausea, vomiting, and vaginal bleeding.She stated she had been spotting for five days and soaking up to four pads a day. Her last menstrual period was two months before, and a home pregnancy test was positive. Her presentation was...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
Semin Reprod Med 2017; 35: 494-498 DOI: 10.1055/s-0037-1607240Uterine fibroids (UF; aka leiomyoma, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70 to 80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pelvic bulk symptoms, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 34 billion dollars annually in the United States alone. Recently, somatic mutations in exons 1 and 2 of Med12 gene emerged as common UF driver mutations. Unfortunately,...
Source: Seminars in Reproductive Medicine - Category: Reproduction Medicine Authors: Tags: Review Article Source Type: research
Conclusion The increase in antimicrobial resistance towards drugs used to treat gonorrhoea is reaching a critical stage, especially given how common the infection is worldwide, with an estimated 78 million new cases in 2012. This study raises concerns around an important topic while also proposing strategies to help address the slow pace of research and development of new drugs. The prevention of gonorrhoea is equally, if not more, important. The most effective way to prevent gonorrhoea is to always use a condom during sex, including anal and oral sex. Read more advice about sexually transmitted infections and how to prev...
Source: NHS News Feed - Category: Consumer Health News Tags: Medication QA articles Source Type: news
Andrea Syrtash was first hospitalized at the age of 14 for painful and heavy menstrual cycles due to endometriosis. She had no idea her condition would affect her fertility ― and even if she had known, she may not have thought to address it without guidance from her doctors. After six years of trying to conceive, Syrtash, who’s now in her 40s and works as a relationship and dating expert, recently founded pregnantish, a website for singles, couples and LGBTQ people who are trying to conceive.  “When you’re a teenager, it’s not on your mind,” she said. Had she known, “I migh...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
There’s a new hormonal IUD in town: Kyleena, the first device of its kind meant to offer long-lasting contraception to women who have never been pregnant.  Kyleena was approved by the U.S. Food and Drug Administration Monday and will be available in October, part of a new surge in IUD offerings in recent years: Skyla appeared in 2013 as the first FDA-approved IUD in 12 years, and Liletta was approved in 2015.  IUDs are a common form of long-acting reversible contraception, or LARCs, that last for several years. The rapid development in the IUD market ― there are now five options total ― coincides w...
Source: Science - The Huffington Post - Category: Science Source Type: news
CONCLUSIONS: It is uncertain whether endometrial injury improves the probability of pregnancy and live birth/ongoing pregnancy in women undergoing IUI or attempting to conceive via sexual intercourse. The pooled results should be interpreted with caution as we graded the quality of the evidence as either low or very low. The main reasons we downgraded the quality of the evidence were most included studies were at a high risk of bias and had an overall low level of precision. Further well-conducted RCTs that recruit large numbers of participants and minimise internal bias are required to confirm or refute these findings. ...
Source: Cochrane Database of Systematic Reviews - Category: Journals (General) Authors: Tags: Cochrane Database Syst Rev Source Type: research
ConclusionThis observational study reviewed the reliability of different measurements taken at a transvaginal ultrasound scan to diagnose miscarriage during early pregnancy. The recommended cut-off values for gestational sac diameter and embryo crown-to-rump length were changed in 2011 based on a number of reports, with mixed findings suggesting previous ones may have been unreliable. This study looked at the performance of currently used cut-off values, and found that the current cut-offs used to diagnose miscarriage are reliable. No healthy, continuing pregnancies would be wrongly diagnosed as miscarriage using thes...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Pregnancy/child Source Type: news
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