GI highlights from the literature

In this study, the authors have dissected the role of a complex signalling network involving the Hippo, Notch and Wnt/β-catenin pathways on HCC formation and growth. Inactivation of liver Hippo signalling using transgenic mice deficient for mammalian sterile 20-like kinases (MST1 and MST2) resulted in augmentation of the activity of the transcription factors YAP and TAZ and the spontaneous development of HCC in 100% of mice. Hence, the authors confirmed a...
Source: Gut - Category: Gastroenterology Authors: Tags: JournalScan Source Type: research