ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1

Conclusions
The tumourigenic capacity of ZEB1 depends on its inhibition of cancer cell senescence through the activation of a herein identified new molecular pathway. These results set ZEB1 as a potential target in therapeutic strategies aimed at inducing senescence.

Source: Gut - March 10, 2017 Category: Gastroenterology Authors: de Barrios, O., Gyorffy, B., Fernandez-Acenero, M. J., Sanchez-Tillo, E., Sanchez-Moral, L., Siles, L., Esteve-Arenys, A., Roue, G., Casal, J. I., Darling, D. S., Castells, A., Postigo, A. Tags: Colon Source Type: research