Effect of bisphosphonate initiation at week 2 versus week 12 on short-term functional recovery after femoral neck fracture: a randomized controlled trial

ConclusionsWhile underpowered, the findings of this study suggest that there were no significant differences in short-term functional recovery or significant adverse events between the two bisphosphonate groups. Thus, the initiation of bisphosphonate therapy may be considered as early as 2 weeks after femoral neck fracture. It is important that low serum calcium and vitamin D status must be corrected with calcium and vitamin D supplementation prior to or at the time of bisphosphonate initiation.Clinical trial registration numberThis study was registered in the database via the Protocol Registration and Results System (PRS) (NCT02148848).
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research