Simultaneous Interference with HER1/EGFR and RAC1 Signaling Drives Cytostasis and Suppression of Survivin in Human Glioma Cells in Vitro.

In conclusion, we demonstrate that combined treatment of human glioma cell lines in vitro with erlotinib and NSC23766 markedly inhibits cell division, induces apoptosis independent of caspase-3 activation and induces autophagy concomitant with suppression of survivin. PMID: 28271323 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28271323?dopt=Abstract

Source: Neurochemical Research - March 6, 2017 Category: Neuroscience Authors: Karpel-Massler G, Westhoff MA, Kast RE, Dwucet A, Karpel-Massler S, Nonnenmacher L, Siegelin MD, Wirtz CR, Debatin KM, Halatsch ME Tags: Neurochem Res Source Type: research