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Hormone replacement therapy reduces risk of early death

Women who use hormone replacement therapy have significantly decreased risk of heart attack or stroke, according to a study being presented at the American College of Cardiology’s 66th Annual Scientific Session& Expo on 17 March.Telegraph
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Authors: Hanefeld C, Haschemi A, Lampert T, Trampisch HJ, Mügge A, Miebach J, Kloppe C, Klaaßen-Mielke R Abstract BACKGROUND: Persons of lower socio-economic status are at higher risk of disease, especially with respect to severe and chronic illnesses. To date, there have not been any studies with large case numbers regarding acute medical emergencies in this population. METHODS: In a retrospective study, data were obtained on all cases treated by emergency physicians in Bochum, Germany, in 2014/2015, including the diagnoses that were made by the emergency physicians. There were a total of 16 767 cas...
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
A study inDiabetologia reports that early diagnosis of type-2 diabetes is associated with an increased risk of death from heart attack and stroke. Daily Mail
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
ConclusionsOur results provide important information about the comparative cardiovascular safety of NSAIDs in patients with hypertension.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: DRUG SAFETY Source Type: research
by Bernhard Voelkl, Lucile Vogt, Emily S. Sena, Hanno W ürbel Single-laboratory studies conducted under highly standardized conditions are the gold standard in preclinical animal research. Using simulations based on 440 preclinical studies across 13 different interventions in animal models of stroke, myocardial infarction, and breast cancer, we compared the accuracy of effect size estimates between single-laboratory and multi-laboratory study designs. Single-laboratory studies generally failed to predict effect size accurately, and larger sample sizes rendered effect size estimates even less accurate. By contrast, mu...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
Written by Pendell Meyers, edits by Steve SmithThis will be too easy for most long-time readers, but if you are at that level, sit back and enjoy noticing how few milliseconds it takes to recognize this thanks to so many prior examples on this blog!I was sent this ECG from EMS with only the information that it belonged to a middle aged male with left shoulder pain.What do you think?There are hyperacute T-waves in leads V1-V6, as well as in leads II, III, aVF. The J-points are all at baseline with the exception of leads V2-V3 which show a small amount of STD (which makes de Winter morphology in the presence of hyperacute T-...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
This article discusses the potential mechanisms involved and how the risk can be minimised.
Source: Prescriber - Category: Primary Care Authors: Tags: Medicines Optimisation Source Type: research
In Krafcik's analysis of outcomes after 75,943 primary carotid endarterectomies (CEAs) and 140 redo CEAs from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP), redo CEA was associated with significant increases in 30-day stroke (5.0% vs 1.6%), 30-day death/stroke/myocardial infarction (7.1% vs 3.0%), and operation times (137  minutes vs 116 minutes).1 The authors concluded, “Alternatives such as medical management or carotid stenting should be further investigated in this high-risk population.”
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Clinical research study Source Type: research
AbstractPurpose of ReviewThe role of aspirin in secondary cardiovascular prevention is well understood; however, the role in primary prevention is less clear, and requires careful balancing of potential benefits with risks. Here, we summarize the evidence base on the benefits and risks of aspirin therapy, discuss clinical practice guidelines and decision support tools to assist in initiating aspirin therapy, and highlight ongoing trials that may clarify the role of aspirin in cardiovascular disease prevention.Recent FindingsIn 2016, the USPSTF released guidelines on the use of aspirin for primary prevention. Based on 11 tr...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Conclusion Blood Pb and Cd levels which reflect short term exposure were not significantly different in AMD patients and the control group. The difference was not significant either after involvement of previous or current smoker subjects.
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Conclusion The overall benefit with invasive strategy comes from the data of observational studies that are prone to selection bias. We believe that there is a need for a large randomized study in the elderly patients regarding management of NSTEMI.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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