Combretum farinosum Extract Toxicity to Skin and Lung Cell Lines as Measured by the Methylthiazoletetrazolium Assay

Conclusion: Both the roots petroleum ether and roots acetone extracts may have potential use in targeting diseased non-cancerous tissue (e.g., benign tumors) due to their cytotoxicity to normal cell lines. Finally, the roots petroleum ether extract may be the most promising extract for potential use as an anticancer drug if active compounds can be more thoroughly isolated.
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Moustafa T. Gabr, Mohammed S. Abdel-RaziqAbstractNew series of arylsparteine derivatives were synthesized and evaluated for their cytotoxic activity against four human cancer cell lines (cervical epithelial carcinoma cells Hela, breast cancer cells MCF-7, lung cancer cells A549, and glioma cells U87 MG) and one normal fibroblast cell line. Structure-activity relationship revealed that introduction of 4-quinolinyl moiety to sparteine afforded a hybrid compound 10 with considerable antiproliferative activity against all tested cancer cell lines...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
ConclusionSignificant direct effects for sex and numerous childhood cancer types suggests sex-specific factors such as differences in gene expression from the autosomes or the X chromosome, rather than birthweight, may underlie sex differences in tumor risk.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
ConclusionsIn the present cohort, SBRT to the CL-HCC produced excellent treatment response with acceptable HBT and LC. Select HCC patients who are not candidates for surgery or other locoregional therapies can be considered for SBRT to the central liver.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
AbstractPurposeWith a limited overall survival (OS) of 20 months in patients diagnosed with intermediate stage hepatocellular carcinoma (HCC), the preservation of quality of life (QoL) during transarterial chemoembolization (TACE) procedures remains a primary goal. The aim of our study was to evaluate the change in QoL amongst patients undergoing repetitive TACE and to identify specific risk factors that may predict change in QoL.MethodsQoL was assessed in 82 patients undergoing at least two TACE, before and 14 days after TACE, using validated EORTC QLQ-C30 and EORTC HCC18 questionnaires. Tumour response was assessed using...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsIn contrast to previous observations in high-grade EC, our study provides compelling evidence that LND, in particular systematic lymphadenectomy, is not beneficial for patients with type I FIGO IB EC in terms of long-term OAS and RFS.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionCXCR4 may be a promising target for diagnostics and therapy in both SCLC and NSCLC.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Li J, Zhang L, Xie Q, Wang W, Hua Y, Sun Z Abstract Purpose: To evaluate the efficacies of 125I seed implantation and stereotactic body radiation therapy (SBRT) in treatment of recurrent lung metastases from colorectal cancer, to compare the tolerance of lung tissue to both forms of radiotherapy, and to analyze the factors that affect the prognosis. Material and methods: According to treatment received, thirty colorectal cancer patients with post-operative lung metastases were separated into two groups: 125I seed implantation group (group A; n = 16) and SBRT group (group B; n = 14). Patients were follo...
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
Conclusions: Physical and nutritional prehabilitation in older patients with CRC has not shown a significant reduction in postoperative complications or length of stay. One study that examined the effect of a perioperative nutritional supplement reported a reduction in postoperative complications. Future research should explore targeted combined interventions, taking into account physical and nutritional patient requirements.
Source: Journal of Geriatric Physical Therapy - Category: Physiotherapy Tags: Systematic Review Source Type: research
Publication date: 20 December 2018Source: Sensors and Actuators B: Chemical, Volume 277Author(s): Xiaoe Zhang, Yinong Liu, Yiwen Yang, Junjie Huang, Haitao Wang, Zirui Zhu, Xi Wang, Pei Ma, Xin Zhou, Shaoru Wang, Xiang ZhouAbstractMiRNA is reported as an important biomarker candidate and therapeutic target in a variety of diseases and cancers. However, ultrasensitive, straightforward, isothermal, low-cost and credible methods for the detection of miRNA from clinical specimens still remain challenges. Here, we establish an isothermal, highly sensitive and specific method for miRNA analysis based on a novel ligation-promoted...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Abstract Systemic inflammatory-, immunological- and nutritional-based indices, such as the neutrophil-to-lymphocyte ratio (NLR), the prognostic nutritional index (PNI) and the Glasgow prognostic score (GPS), are drawing considerable research attention to predict the long-term prognosis of many types of cancer. Recently, these parameters have also been reported to be useful in predicting postoperative morbidity in several fields, including colorectal and otolaryngological cancer. However, while distal cholangiocarcinoma exhibits a high morbidity rate, its risk factors of morbidity have not yet been established. Thi...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Mol Clin Oncol Source Type: research
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