An open-label clinical trial to investigate the efficacy and safety of corifollitropin alfa combined with hCG in adult men with hypogonadotropic hypogonadism.

CONCLUSIONS: Corifollitropin alfa 150 μg administrated every other week combined with twice-weekly hCG for 52 weeks increased testicular volume significantly, and induced spermatogenesis in >75% of men with HH who had remained azoospermic after hCG treatment alone.
TRIAL REGISTRATION: ClinicalTrials.gov: NCT01709331 .
PMID: 28270212 [PubMed - in process]

Source: Reproductive Biology - March 6, 2017 Category: Reproduction Medicine Authors: Nieschlag E, Bouloux PG, Stegmann BJ, Shankar RR, Guan Y, Tzontcheva A, McCrary Sisk C, Behre HM Tags: Reprod Biol Endocrinol Source Type: research