Attenuation of Helicobacter pylori -induced gastric inflammation by prior cag − strain (AM1) infection in C57BL/6 mice

ConclusionsThese data suggested that priorH. pylori cag− strain infection attenuated the severity of gastric pathology induced by subsequentcag+ strain in C57BL/6 mice. Prior AM1 infection induced Th1 cytokine IFN- γ, which reduced the Th17 response induced by subsequent SS1 infection. The reduced gastritis in AM1/SS1-infected mice might also be due to enrichment of AM1- primed Treg cells in the gastric compartment which inhibit Th1 and Th17 responses to subsequent SS1 infection. In summary, prior infection b y non-virulentH. pylori strain (AM1) causes reduction of subsequent virulent strain (SS1) infection by regulation of inflammatory cytokines and MMPs expression.
Source: Gut Pathogens - Category: Microbiology Source Type: research