Liver transplantation for hepatobiliary malignancies: a new era of “Transplant Oncology” has begun
In conclusion, liver transplantation is an important optio n for hepatobiliary malignancies; however, prospective studies are urgently needed to ensure the appropriate patient selection, organ allocation and living donation policies, and administration of antineoplastic immunosuppression.
No abstract available
Link to case here: Liver Failure [Medication-Induced] This case has an expert witness opinion from a GI doc. Patient was started on Depakote, LFTs were initially fine. Within 5 weeks she had a liver transplant. The expert notes that she had positive ASMA and ANA titers and homozygous positive for H63D hemochromatosis. Do these results suggest that there may be an alternative cause for her liver failure?
HEART disease: Around twice as many people are living with heart and circulatory diseases in the UK than with cancer and Alzheimer's disease combined according to the British Heart Foundation. Could a seemingly innocent and popular drug be contributing to these shocking statistics?
AbstractGasdermins (GSDM) are members of a family of pore-forming effector proteins which lead to membrane permeabilization and pyroptosis, a lytic cell death with pro-inflammatory characteristics. Recently, two members of the gasdermin family, gasdermin B (GSDMB) and gasdermin E (GSDME), were shown to suppress tumor growth, through the involvement of cytotoxic lymphocytes. Other studies also reported the important functions of gasdermins in various cancer types including gastric cancer, hepatocarcinoma, and cervix and breast cancer. However, gasdermins have not been previously studied in the context of serous ovarian canc...
This study provides pilot data for the further development ofL. casei exoproducts as an anti-inflammatory or anti-proliferative agent for the treatment of inflammatory and cancer diseases in gut. However, more data is needed before final conclusions ofL. casei cell-free supernatant ’s efficacy can be drawn.
AbstractGranzyme B –producing B cells have been reportedly reported to be an important regulatory B cell subset in the pathogenesis of many diseases. However, its role in liver transplant recipients with acute rejection has never been well elucidated. Seventeen liver transplant recipients with acute rejection and 25 controls with stable liver function were enrolled in this study to determine the function of granzyme B–producing B cells via flow cytometry. Liver transplant recipients with acute rejection had higher expression of granzyme B in CD19+B cells when compared with controls. Following rejection, the gra...
More than two in five (42%) teaching assistants, caretakers, cleaners and other school support staff in England and Wales are actively looking for better paid jobs because of the rising cost of living and persistent low pay in education, according to a UNISON survey released today (Friday). The survey responses paint a bleak picture of school employees living with no heating or hot water because of broken boilers they can’t afford to fix, worrying about how to pay for dental treatment, relying on their children for money, or going to food banks. The findings reveal an overwhelming majority (96%) say the r...
Elizabeth Goldman, 29, from Mobile, Alabama, is set to be the first woman in the state to undergo a uterus transplant. She was born with a condition called MKRH Syndrome and has no uterus.
Health care costs in the U.S. have increased dramatically over the past five decades, from $74 billion in 1970 to $3.8 trillion in 2019. This trend has been fueled in large part by an increase in the number of people who struggle with chronic conditions such as cancer, diabetes, hypertension, and lung disease. Stanford UniversityRead more …How advanced analytics can help social determinants of health originally appeared inKevinMD.com.
Lab Chip, 2021, Advance Article DOI: 10.1039/D1LC00801C, PaperHyeono Nam, Hyung Jin Sung, Jinsoo Park, Jessie S. Jeon TSAWs quickly form a tumor spheroid for a drug screening platform. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
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