New study: polydatin blasts myeloma cells to smithereens

Discussion part, where the researchers state that polydatin was found to be less toxic to normal cells. Does that mean it was somewhat toxic to normal cells, though less so, compared to cancer cells? I couldn’t find an answer…can anyone else find it? Reading on, we see that polydatin (or PD, for short), “functioned as a tumor suppressor in MM cells.  The proliferation of MM cells decreased and apoptosis increased progressively along with the increasing concentrations of PD.” Super duper…again. The study concludes that “PD effectively suppressed cell growth and induced apoptosis and autophagy in MM cells through mTOR/p70s6k signaling pathway in vitro, which indicates that PD could be used as a potential anticancer drug for MM treatment. However, further research is needed to explore the anticancer effect of PD in vivo.” Just one last comment on mTOR, that is, polydatin’s target. And here I’m taking from my own research: mTOR is a really nasty pathway involved with myeloma disease progression. When mTOR is activated, MM cell lines resist being killed. Obviously, not good at all. And, in fact, if you do a search of PubMed, mTOR inhibitors are being developed all over the place to treat myeloma. Okay, so more studies (in vivo ones, especially) are needed, blablabla. But what I find tremendously significant is that this new study proves that the interest in finding new plant extracts that might possibly be useful in the trea...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll cancer Japanese knotweed myeloma polydatin Source Type: blogs