Population model of bladder motion and deformation based on dominant eigenmodes and mixed-effects models in prostate cancer radiotherapy

Prostate cancer is one the most common cancer types worldwide. One of the standard treatment methods is external radiotherapy, which involves delivering ionizing radiation to a clinical target, namely the prostate and seminal vesicles. Due to the uncertain location of organs during treatment, consisting around 40 radiation fractions delivering a total dose ranging from 70 to 80Gy, safety margins are defined around the tumor target upon treatment planning. This also leads to portions of healthy organs neighboring the prostate or organs at risk – the bladder and rectum – to be included in the target volume, potentially resulting in adverse events affecting patients’urinary (hematuria and cystitis, among others) or rectal (rectal bleeding, fecal incontinence, etc.) functions.

Source: Medical Image Analysis - March 7, 2017 Category: Radiology Authors: Richard Rios, Renaud De Crevoisier, Juan D. Ospina, Frederic Commandeur, Caroline Lafond, Antoine Simon, Pascal Haigron, Jairo Espinosa, Oscar Acosta Source Type: research