Behavioral and Stereological Analysis of the Effects of Intermittent Feeding Diet on the Orally Administrated MDMA ( “ecstasy”) in Mice

Conclusion—IF regimen can significantly modify various behavioral characteristics induced by MDMA and promotes faster recovery from MDMA’s anxiogenic effects. Additionally, IF regimen had neuroprotective effects on the neurons of the CA1 area of the hippocampus after a single oral dose of MDMA. We believe the results of our study support the need for further research examining the behavior modifying and neuroprotective potential of the IF?regminen for the treatment of drug addiction in humans. Introduction MDMA, or 3,4-methylenedioxy-methamphetamine, is a chemical compound that is commonly used as a psychoactive recreational drug of abuse. Its reported effects are enhanced energy, endurance, sociability, psychodelic hallucinations, and sexual arousal.[1,2] “Ecstasy” (also known as “XTC,” “E,” or “X”) and “molly” are popular “street” names for MDMA, though it’s important to note that some formulations of ecstacy/molly may be contaminated with other amphetamines or may not actually contain 3,4-methylenedioxymeth-amphetamine at all.[2,3] MDMA is usually consumed orally in 80 to 250mg tablet form (rarely capsules). Often 2 to 3 tablets are taken together.[4] MDMA is listed as a Schedule 1 drug by the United States Drug Enforcement Agency, meaning that currently there are no accepted medical uses for MDMA in the United States, there is a lack of accepted safety for use under medical supervision, and there is a high potential for abuse.[5] However, MDM...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Anxiety Disorders Behavioral and Cognitive Neurology Current Issue Original Research Psychiatry Substance Use Disorders Elevated plus-maze hippocampus intermittent feeding MDMA neuronal numerical density open field Source Type: research