Synthesis of 5-nitro-salicylaldehyde-N-substituted thiosemicarbazonates of copper(II): Molecular structures, spectroscopy, ESI-mass studies and antimicrobial activity

Publication date: 1 May 2017 Source:Inorganica Chimica Acta, Volume 461 Author(s): Tarlok S. Lobana, Shikha Indoria, Henna Sood, Daljit S. Arora, Balwinder S. Randhawa, Isabel Garcia-Santos, Victoria A. Smolinski, Jerry P. Jasinski Equimolar reactions of copper(II) acetate with 5-nitro-salicylaldehyde-N1-substituted thiosemi carbazones, [5-NO2-2-HO–C6H4-C2(H)N3–N2H–C1(S)–N1HR; R=Me, H2L-NHMe; Et, H2L-NHEt; Ph, H2L-NHPh; H, H2L-NH2], and 4,4′-dimethyl-2,2′-bipyridine (dm-bipy), 2,9-dimethyl-1,10-phenanthroline (dm-phen) and 3,4,7,8-tetramethyl-1,10-phenanthroline (tm-phen) have yielded complexes of stoichiometry, [Cu(κ3-O,N,S-5-NO2-stscN1HR)(κ2-N,N-L′)] {R=H (1, 2, 3), Me (4, 5, 6), Et(7, 8, 9), Ph (10, 11, 12); L′=dm-bipy (1, 4, 7, 10)/dm-phen (2, 5, 8, 11)/tm-phen (3, 6, 9, 12)}. They have been investigated by analytical data, infrared and electronic absorption spectroscopy, electron spin resonance spectroscopy, fluorescence activity, ESI-mass study and single crystal X-ray crystallography (1, 6, 7). The geometry of complexes is slightly distorted square pyramidal and have displayed weak to intense fluorescence in the region, 370–570nm. Complexes have shown significant antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA), Staphylococcus aureus (MTCC740), Klebsiella pneumoniae (MTCC109), Shigella flexneri (MTCC1457), Salmonella typhimurium (MTCC-439), and Candida albicans (MTCC227). Complexes are cytotoxic against liv...
Source: Inorganica Chimica Acta - Category: Chemistry Source Type: research