pH-Dependent behavior of novel gellan beads loaded with naproxen.

pH-Dependent behavior of novel gellan beads loaded with naproxen. Curr Drug Deliv. 2017 Mar 03;: Authors: Szybowicz M, Hyla K, Białas M, Milanowski B, Froelich A, Osmałek T Abstract We have designed, formulated and characterized low-acyl gellan gum (GG) macrobeads to be applied as potential carriers for the delivery of naproxen (NPX) to the distal parts of the gastrointestinal tract. The beads were obtained by ionotropic gelation technique. CaCl2 solution (1%, 9.0×10-2 M) was used as a cross-linking medium. Nine different polymer, drug and surfactant (Tween®80) mixtures were used for beads production. The surface and morphology of the dried beads were analyzed by SEM. Raman spectra of NPX powder and the beads confirmed that NPX did not undergo structural changes during production process. DSC studies showed that thermal decomposition at lower temperatures was observed for formulations with the lowest amount of GG. The beads obtained from mixtures containing 0.5% of GG were not spherical and thus eliminated from further experiments. The remaining beads revealed 13.9-39.9% of drug loading and 75.3-99.7% drug encapsulation efficiency. The swelling and degradation behavior of the beads were evaluated in four simulated gastrointestinal fluids with different pH (1.2; 4.5; 6.8 and 7.4). The NPX in vitro release studies were conducted on USP I apparatus (rotating basket) at pH=7.4 and compared to the commercial enteric tablet. PM...
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Deliv Source Type: research