Joining the dots: Can UW ‐QoL free‐text data assist in understanding individual treatment experiences and QoL outcomes in head and neck cancer?

Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: CLINICAL CORRESPONDENCE Source Type: research

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AbstractIntroductionThe purpose of this study was to review our recent experience of salvage surgery, comparing larynx and oropharynx recurrence patterns.MethodsA single centre, retrospective review of salvage surgery for recurrent head and neck cancer including patients between 2008 and 2016.Results61 patients were identified, 36 underwent salvage laryngectomy and 25 received oropharyngeal resections. The median overall survival of oropharyngeal recurrent tumors was 26 months (95% CI 15 –118 months) and for laryngeal tumors was 23 months (95% CI 11–38 months),p = 0.1008. There was a significant o...
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
AF Alfouzan, Nigerian Journal of Clinical Practice 2019 22(1):1-8 This review summarizes the development of head and neck pathology. Over the last decades, head and neck pathology cancer science began to examine the behavior of these cancers and to uncover the causative factors that lead to head and neck cancer. The avoidance of certain discovered carcinogens, lifestyle changes and certain vaccinations can reduce the risk of these cancers. Efforts in pathology are ongoing to aid the prevention and to delay the development of head and neck cancer.
Source: Nigerian Journal of Clinical Practice - Category: Rural Health Authors: Source Type: research
AbstractBackgroundNo predictive biomarker of immune checkpoint inhibitors in head and neck squamous cell carcinoma (HNSCC) has been well established. The impact of programmed death-ligand 1 (PD-L1) expression, CD8+ tumor-infiltrating lymphocytes (TILs), and p16 status in HNSCC is unclear and may vary according to ethnicity.MethodsHNSCC patients treated between 2007 and 2013 were reviewed. Archival tissues were retrieved for PD-L1, CD8+ TILs, and p16 analyses. PD-L1 expression was evaluated by using the validated SP142 assay on the VENTANA platform. CD8+ TILs were defined by using semiquantitative scoring.ResultsA total of ...
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research
This study sought to improve understanding of the intervals from first symptom recognition to diagnosis for HNC and investigate associations between patient-reported symptoms and socio-demographic factors.MethodsPeople within 3 months of diagnosis, completed a researcher-administered questionnaire and data were extracted from primary and secondary care clinical records.ResultsEighty (mean age 62.9 [SD 11.7] years; 66% men) were interviewed. The appraisal interval was longer than a month for 39% of participants and the help-seeking interval was longer than a week for 44%. The median diagnostic interval was 92 (IQR; 34-172) ...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
We present a case of a 43-year-old man with accidental finding of asymptomatic fourth pouch cyst and fistula following follicular thyroid cancer surgery. The day after the surgery, suction bottle was filled with little white crumbs and the wound started to suppurate. Barium swallow revealed the presence of a fistulous canal that arose from the left pyriform sinus. Meanwhile, the pathologist confirmed the presence of a lateral neck cyst within this thyroid lobe. The patient was operated on but fistulous canal was not visualized. In the meantime, wound discharge ceased spontaneously. At 1-year follow up, the patient was stil...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research
AbstractPurpose of ReviewTo review the role of frailty and comorbidities in determining operability and associated outcomes in patients with oral and oropharyngeal squamous cell carcinoma.Recent FindingsFrailty and comorbidity have been linked to multiple adverse outcome measures including risk of mortality, surgical complications, length of stay, intensity of care needs, discharge disposition, risk of readmission, and cost of healthcare delivery. There are diverse objective and validated measures of comorbidity and frailty. Addition of comorbidity and objective frailty measurements has been demonstrated to improve predict...
Source: Current Otorhinolaryngology Reports - Category: ENT & OMF Source Type: research
ConclusionA posttreatment intervention aimed at increasing CV and GLV intake in HNC survivors is feasible. A larger RCT is needed to assess the efficacy of this intervention on disease outcomes.
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
Conditions:   Head Cancer;   Facial Cancer;   Neck Cancer;   Upper AerodigestiveTract Cancer;   Oral Cancer Interventions:   Drug: Birinapant;   Radiation: Intensity modulated re-irradiation therapy (IMMRT) Sponsor:   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In this study, the expression levels of distinct miRNAs extracted from formalin-fixed, paraffin-embedded (FFPE) samples of oral squamous cell carcinoma were compared.ResultsStatistical analysis revealed significant correlations between distinct miRNAs and disease recurrence (miR-99*, miR-194*; p
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
Publication date: Available online 17 January 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): S. Langton, J.A. Rijken, C.R. Bankhead, A. Plüddemann, C.R. LeemansAbstractOne-year survival after head and neck cancer in England has been reported to be worse than that in Europe, despite five-year conditional survival being similar, which implies that patients present later in England. One country with better rates is The Netherlands. There are many possible causes, one of which may be the system of referral from primary to secondary care. We have compared the views of secondary care specialists in ...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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