Joining the dots: Can UW ‐QoL free‐text data assist in understanding individual treatment experiences and QoL outcomes in head and neck cancer?
The majority of patients receiving radiation therapy will experience a skin reaction, ranging from mild erythema to severe moist desquamation. Physical changes to the skin can have a negative effect on daily activities, mood and body image, sense of independence and self-care. No research has been published on the experiences of patients with head and neck cancer (HNC) patients and their skin reactions. This qualitative study sought to address a gap in our understanding of how these patients perceive and address the impact of a skin reaction.
During radiotherapy (RT) treatment, variations such as patient weight loss, tumor regression and diminution of the volume of organs at risk (OARs) may occur. These discrepancies may result in changes in the dose distribution with a risk of overdose to the OARs which cannot be compensated for by a simple rigid repositioning. In order to more easily prioritize these variations according to their potential impact, an image-guided Traffic Light Protocol (IG-TLP) has been put into practice as a decision support system (DSS).
Conclusion Our results revealed that APO, C1, and A5 exhibit cytotoxic effects in HNSCC cells. The mechanisms of action appear to be partly via the generation of DNA damages and apoptosis induction through Caspase-3 pathway activation. This study provides preclinical data that suggest a potential therapeutic role for APO, C1, and A5 against head and neck cancer cells.
Salivary gland carcinoma is rare among head and neck cancers. Sublingual gland carcinoma, a type of salivary gland carcinoma, is even rarer; therefore, the number of cases at a single institute is too small for sufficient evaluation of tumor characteristics. We conducted a multicenter, retrospective analysis of sublingual gland carcinomas in patients who visited 12 institutions associated with the Kyoto Hospital and Affiliated Facilities Head and Neck Clinical Oncology Group.
ConclusionThis work demonstrates the strong preliminary support of18F-KS1, both in vitro and in vivo for imaging ROS in cancer. If successful, this work will provide a new paradigm to directly probe real-time oxidative stress levels in vivo. Our work could enhance precision medicine approaches to treat cancer, as well as neurodegenerative and cardiovascular diseases affected by ROS.
Condition: Head and Neck Cancer Intervention: Other: Helical intensity-modulated radiotherapy (IMRT) Sponsor: Institut Claudius Regaud Not yet recruiting
We investigated the risk of thyroid disorders, namely hypothyroidism, thyrotoxicosis and thyroiditis, in head and neck cancer patients undergoing multimodal treatment.
ConclusionsThis initial experience shows that harvesting free flaps and performing microanastomoses with the 3D 4K exoscopic system are feasible. Further studies on larger series are warranted to explore if the applicability of this technology to other fields of head and neck surgery can compensate for its costs.Level of Evidence: Level V, therapeutic study
This report is about a patient with metastastic squamous cell cancer of the head and neck refractory to nivolumab monotherapy, who showed a remarkable response to combination therapy with nivolumab and ipilimumab over a period of 2 years, but developed serious renal failure and a Takotsubo cardiomyopathy.
ConclusionSimultaneously performed major tumor surgery was the most common indication for a tracheostomy. A notable number of patients had impaired physical status, but relatively insignificant comorbidities. Almost two-thirds of the patients were decannulated during follow-up, although some patients remained tracheostomy dependent for a prolonged period. Tracheostomy was found to be a safe procedure.Level of evidence2b.