Effect of Food Thickener on the Inhibitory Effect of Mitiglinide Tablets on Post-prandial Elevation of Blood Glucose Levels
AbstractThe aim of this study was to examine the effect of food thickener on the pharmacodynamics of mitiglinide (MGN), a drug belonging to a class of rapid-acting insulin secretagogues. First, MGN tablets were coated by immersion in a xanthan gum-based food-thickening agent. This treatment was shown to delay disintegration rates of MGN tablets in vitro. The pharmacodynamics of MGN after ingestion of a single oral dose of an MGN tablet, with or without food thickener immersion, were then examined in an open-label crossover study comprising 5 healthy participants. It was observed that after administration of 75 g of oral glucose, the area under the blood glucose concentration–time curve was larger for treatment with MGN tablets that had been immersed in the food thickener than for nonimmersed tablets. The maximum blood glucose level was also higher in treatments with MGN tablets that had been immersed in food thickener. The extended time of higher glucose levels associated with thickener-immersed MGN tablets given to human volunteers may be associated with the reduced disintegration rates of immersed MGN tablets as observed in the in vitro experiment. Overall, our study suggests that commercially available food thickeners influence the pharmacodynamics of MGN and that their use should therefore be carefully assessed and monitored in certain clinical situations.
European Union, European Centre for Disease Prevention and Control. 11/21/2017 This 24-page report summarizes visits and meetings held on May 29- June 2, 2017, to discuss antimicrobial resistance (AMR) issues in Luxembourg with the overall objective of providing an evidence-based assessment of the situation in Luxembourg regarding prevention and control of AMR through prudent use of antibiotics and infection control. The report provides an overview, observations, and options for action. (PDF)
U.S. Environmental Protection Agency, Office of Research and Development, National Homeland Security Research Center. 09/2017 This 69-page document reports on a project to evaluate the efficacies of several remediation options for infrastructure or equipment contaminated with chemical agents, and qualitatively measure the effect of the decontaminant on the building material. Four commercially available decontaminant solutions were quantitatively evaluated for their ability to decontaminate two persistent chemical warfare agents (VX and HD) on permeable surfaces associated with subway-related materials of construction. (PDF)
U.S. Environmental Protection Agency, Office of Research and Development, National Homeland Security Research Center. 07/2017 This 104-page document is a second edition of the first ever detailed and step-by-step protocol published by EPA in 2012. This protocol includes three analytical methods for the detection of B. anthracis spores in various environmental samples (e.g., aerosols, particulates, and drinking water). The protocol has been specifically developed for the analysis of environmental samples during an incident involving contamination from B. anthracis spores. (PDF)
CONCLUSION: Despite public health messages concerning the adverse impact of alcohol consumption, a sizeable proportion of Alberta's Tomorrow Project participants consumed alcohol in excess of cancer prevention recommendations. Continued strategies to promote low-risk drinking among those who choose to drink could impact future chronic disease risk in this population. PMID: 29236379 [PubMed - in process]
CONCLUSION: Our study contributes to the growing body of evidence that BPA is positively associated with obesity. Prospective studies with repeated measures are needed to address temporality and improve exposure classification. PMID: 29236378 [PubMed - in process]
CONCLUSION: ELPH's application of Xpey' Relational Environments serves as an example of the analytic framework's utility for exploring and conceptualizing Indigenous health equity in BC's public health system. Future applications of the framework should be embedded in Indigenous research methodologies. PMID: 29236377 [PubMed - in process]
A recently published scientific review led by URMC associate professor of Psychiatry Marc Swogger, Ph.D., may help reduce misconceptions about the controversial plant kratom and highlight its potential as a tool to treat opioid addiction that deserves more research. The study points to kratom's potential as a safer substitute for opioids and suggests it also may help reduce negative mood and relieve anxiety.
Hello guys, I've been lurking around recently but I needed to get honest feedback from you guys on my situation. So I am a 5th-year senior studying Biochemistry. cGPA is low (3.29) but sGPA is ok(3.68). I'm in a sticky situation. I started college funding my own tuition due to no financial aid due to my immigration status (DACA) but failing classes. I worked 50+ hours to pay tuition but managed classes very poorly. My GPA was a 1.5 in Exercise Science (yikes!). I was involved in an... Your thoughts on my situation(immigrant pre med)?
Authors: Orr DMR, Preston-Shoot M, Braye S Abstract Hoarding has become increasingly prominent in clinical practice and popular culture in recent years, giving rise to extensive research and commentary. Critical responses in the social sciences have criticised the cultural assumptions built in to the construct of 'hoarding disorder' and expressed fears that it may generate stigma outweighing its benefits; however, few of these studies have engaged directly with 'hoarders' themselves. This paper reports on in-depth, semi-structured interviews with 10 individuals living in England, who received assessment and interve...
US AMG taking it for the first time. Major Mistakes: 1. Completely forgot to wear gloves/wash hands at one station. 2. Forgot to counsel a patient about the use of a substance he was getting from a friend. It wasn’t central to the case but it was a big deal. 3. From a menorrhea case I completely lost my head about the differential and did not list fibroids/polyps as a diagnosis. She couldn’t get pregnant for 6 months and I put asherman, adenomyosis but no fibroids. I did say there’s may be... Took on 12/13, think I may have failed :/