Effect of Food Thickener on the Inhibitory Effect of Mitiglinide Tablets on Post-prandial Elevation of Blood Glucose Levels
AbstractThe aim of this study was to examine the effect of food thickener on the pharmacodynamics of mitiglinide (MGN), a drug belonging to a class of rapid-acting insulin secretagogues. First, MGN tablets were coated by immersion in a xanthan gum-based food-thickening agent. This treatment was shown to delay disintegration rates of MGN tablets in vitro. The pharmacodynamics of MGN after ingestion of a single oral dose of an MGN tablet, with or without food thickener immersion, were then examined in an open-label crossover study comprising 5 healthy participants. It was observed that after administration of 75 g of oral glucose, the area under the blood glucose concentration–time curve was larger for treatment with MGN tablets that had been immersed in the food thickener than for nonimmersed tablets. The maximum blood glucose level was also higher in treatments with MGN tablets that had been immersed in food thickener. The extended time of higher glucose levels associated with thickener-immersed MGN tablets given to human volunteers may be associated with the reduced disintegration rates of immersed MGN tablets as observed in the in vitro experiment. Overall, our study suggests that commercially available food thickeners influence the pharmacodynamics of MGN and that their use should therefore be carefully assessed and monitored in certain clinical situations.
"I'm infertile, but I'm also still just me..."
About one-third of adults say they don't usually get enough sleep. Now, there's news of a link between quality of sleep and risk of dementia. Dr. Jon LaPook explains the science behind the new report.
A BRISK 10-minute walk each day could save millions of middle-aged Britons from an early death, research has found.
A SIMPLE scan can accurately predict whether someone will suffer a potentially fatal stroke.
CANCER can be prevented with regular physical activity, but millions in the UK are raising their risk of early death by walking at a brisk pace less than ten minutes a month.
STROKE risk could be predicted after experts developed a new and potentially life-saving MRI scan.
The World Health Organization said the leading cause of death is now lower respiratory tract infections. HIV/AIDS killed 760,000 Africans in 2015, and was the top cause since at least 2000.
The move, unveiled in a policy statement on Wednesday, comes amid a broad effort to battle dangerous superbugs which are becoming increasingly resistant to medication.
The phase information of a complex field is routinely obtained using coherent measurement techniques as, e.g., interferometry or holography. The obtained measurement result is subject to a 2 π ambiguity and is often referred to as wrapped phase. Phase-unwrapping algorithms (PUAs) are commonly ...
Inspection of defects with micrometer level on large aperture surfaces with hundreds of millimeters is one of the challenges in surface quality evaluation. Various microscopic imaging methods have been applied to inspecting the surface defects, while they are time-consuming for the small field of ...