Stable Fluorophores for Optical-Guided Imaging in Surgical Interventions

Researchers in the NCI Chemical Biology Laboratory developed an improved class of heptamethine cyanines fluorophore dyes useful for imaging applications in the near-IR range (750-850 nm). A new chemical reaction provides easy access to novel molecules with improved properties. Specifically, these dyes display greater resistance to thiol nucleophiles, and are more robust while maintaining excellent optical properties.These new dyes have been successfully employed in variousin vivo imaging applications andin vitro labeling and microscopy applications. The NCI inventors continue to develop these dyes as targetable agents for optical-guided surgical interventions.IC: NCINIH Ref. No.: E-271-2014/0Advantages: Greater chemical stability in the presence of thiol nucleophilesMore facile and higher-yielding synthetic preparationSuccessfully utilized forin vivo imaging applicationsApplications: Antibody labelingFACS and related microscopyImaging reagent for surgical interventionsProvider Technology ID: 3111Updated On: Mar 2, 2017Date Published: Thursday, March 2, 2017Provider Classifications: Publications: Patent Application: PCT/US2014/064136Patent Authority: PCTLicensing Contacts: Lead Inventor: Inventor IC: NCINCINCIInventor Lab URL: http://irp.nih.gov/pi/martin-schnermannLPM FIrst Name: LaurenLPM Last Name: Nguyen-AntczakLPM Address: 8490 Progress Drive, Riverside 5, Suite 400LPM City: Fre...

Source: NIH OTT Licensing Opportunities - March 2, 2017 Category: Research Authors: ajoyprabhu3 Source Type: research