Maternal and placental preeclampsia. Physiopathological and geographical differences

Publication date: January 2017 Source:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, Volume 7 Author(s): Pierre-Yves Robillard Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000years ago, we will make a brief presentation of the different major steps in comprehension of pre-eclampsia. (1) 1843 Lever, description of proteinuria, (2) 1903 Cooks & Briggs discovery of gestational hypertension (7years after the invention of the inflatable arm band in 1896 by a young 31year-old Italian physician Riva-Rocci), (3) End of the 1970’s, description of the “double” trophoblastic invasion existing only in humans, (4) between the 1970s and the 1990s, description of preeclampsia being a couple disease. The “paternity problem” (and therefore irruption of immunology), (5) at the end of the 1980s, a major step forward: Preeclampsia being a global endothelial cell disease (glomeruloendotheliosis, hepatic or cerebral vascularitis, HELLP, eclampsia), inflammation, (6) end of the 1990s: Consensus for a distinction between early onset preeclampsia EOP and late onset LOP (34weeks gestation), EOP being rather a problem of implantation of the trophoblast (and the placenta), LOP being rather a pre-existing maternal problem (obesity, diabetes, coagulopathies etc…). LOP is predominant everywhere on this planet, but enormously predominant in developed countries (those who pub...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research