Not 'just girl problems': A Calgary woman's 6-year fight to validate her period pain

An estimated one in 10 women suffer from endometriosis, a condition that is difficult to diagnose and which can cause debilitating pain, cysts and even infertility.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Calgary Source Type: news

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Authors: Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J Abstract Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. The underlying pathologic mechanisms in the intracavitary endometrium and extra-uterine endometriotic tissue involve defectively progr...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
ConclusionsWe have identified menstrual cycle- and endometriosis-associated protein changes linked to various cellular processes that are potential biomarkers and that provide insight into the biology of endometriosis. Our data indicate that the markers tested, whilst not useful alone, have improved diagnostic accuracy when used in combination and demonstrate menstrual cycle specificity. Tissue heterogeneity and blood contamination is likely to have hindered biomarker discovery, whilst a small sample size precludes accurate determination of performance by cycle phase. Independent validation of these biomarker panels in a l...
Source: Clinical Proteomics - Category: Biochemistry Source Type: research
Conclusions and Relevance Cystectomy of ovarian endometriomas has been the first-line treatment for management for many years because it provides improved pain relief, reduces recurrence rates, and was thought to be favorable in in vitro fertilization. However, a growing body of evidence is demonstrating benefit, or at least no harm, in expectant management for asymptomatic patients with small, stable endometriomas. Medical management is often very effective and appropriate first line. When surgical intervention is appropriate, careful ovarian cyst excision with goal of ovarian tissue preservation and treatment of additi...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME ARTICLES Source Type: research
March is Endometriosis Awareness Month.  Endometriosis is a painful condition where endometrial tissue grows outside the uterus. It is estimated that up to 10% of women have endometriosis (Ozkan 2008).   Endometriosis can cause infertility and for women with subfertility the prevalence rate ranges from 25% to 40% (Ozkan 2008). Endometriosis frequently presents with the symptom of pain (Barlow 1993) including dysmenorrhoea (painful periods), dyspareunia (pain during sexual intercourse), and pelvic or abdominal pain.  We invited Edgardo Somigliana, MD-PhD (Dept Clinical Sciences and Community Health, Universit...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
Abstract Endometriosis is characterized by extra-uterine growth of endometrial tissue accompanied by adverse clinical manifestations including chronic pelvic pain and infertility. Retrograde menstruation, the efflux of endometrium into the peritoneal cavity during menstruation, is believed to contribute to implantation of endometrial tissue and formation of endometriotic lesions at ectopic sites. While it is established through various rodent and non-human primate models that endometrial tissue fragments, as well as non-dissociated stroma and glands, are capable of seeding endometriosis in a manner mimicking retro...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
We present an interesting case of a nulliparous patient that underwent laparoscopic surgery for pelvic endometriosis and 2 years after a laparoscopic excision of an intraligamentous fibroid.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Movies Technique 1 – Surgical techniques in Gynaecology Source Type: research
Introduction: Endometriosis is an enigmatic disease affecting up to 10% of reproductive-aged women causing pain and infertility. Deep infiltrating endometriosis (DIE) is the most severe form of the disease. The impact of surgical treatment for deep endometriosis on fertility success rate of assisted reproduction techniques (ART) is not clear.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Session 24 – Reproductive Medicine Source Type: research
Endometriosis is a common gynecologic condition, affecting approximately 10% of reproductive aged women1-3. It commonly presents with pelvic pain, painful periods, and infertility and can significantly impact one ’s quality of life4-6. Early exploration into the pathophysiology of this condition identified race as a risk factor for endometriosis, with the condition predominantly identified in white women7, 8. It is still unclear if there is biological basis for this conviction, or if it can be explained by methodological and social bias that existed in the literature at that time9-11.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Viewpoint Source Type: research
Endometriosis is a common gynecologic condition, affecting approximately 10% of reproductive-aged women.1-3 It commonly presents with pelvic pain, painful periods, and infertility and can significantly have an impact on one ’s quality of life.4-6 Early exploration into the pathophysiology of this condition identified race as a risk factor for endometriosis, with the condition predominantly identified in white women.7,8 It is still unclear whether there is a biological basis for this conviction or whether it can be ex plained by methodological and social bias that existed in the literature at that time.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Viewpoint Source Type: research
Abstract MicroRNAs (miRNAs), a class of small non-coding RNA molecules, have been recognized as key post-transcriptional regulators associated with a multitude of human diseases. Global expression profiling studies have uncovered hundreds of miRNAs that are dysregulated in several diseases, and yielded many candidate biomarkers. This review will focus on miRNAs in endometriosis, a common chronic disease affecting nearly 10% of reproductive-aged women, which can cause pelvic pain, infertility, and a myriad of other symptoms. Endometriosis has delayed time-to-diagnosis when compared to other chronic diseases, as the...
Source: Biology of Reproduction - Category: Reproduction Medicine Authors: Tags: Biol Reprod Source Type: research
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