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First hormone replacement therapy for parathyroid disorder

The European Medicines Agency has recommended granting a conditional marketing authorisation in the EU for an orphan medicine proposed as a treatment for chronic hypoparathyroidism, in patients poorly controlled using standard treatments.European Medicines Agency
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering from Graves ’ disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a methimazole allergy. She was admitted for urosepsis and agranulocytosis. The patient was diagnosed with propylthiouracil related agranulocytosis, diffuse toxic goiter, and thyro-gastric syndrome. Antit hyroid drug therapy was stopped resulting in a worsening of thyrotoxicosis. Agranulocytosis was treated with 8 doses of G-CSF with full recovery. To rapidly restore euthyroidism and to perform a thyroidectomy, the...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
We present an unusual case of SS in a young lady who continued to have normal menstruation after the index event, had two spontaneous pregnancies, and was diagnosed only 11 years later when she presented to us with acute heart failure.
Source: Journal of Postgraduate Medicine - Category: Internal Medicine Authors: Source Type: research
We describe postoperative complications after penile inversion vaginoplasty and evaluate age, BMI, and years on hormone replacement therapy (HRT) as risk factors for complications.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Source Type: research
MN, 50 years old, BMI: 36. Menopause was 7 years ago. No hormone replacement therapy before. She was treated for breast cancer and stopped using tamoxifen two years ago. Asymptomatic. She underwent to a screening transvaginal ultrasound that showed an endometrial thickness of 0.6  cm. Diagnostic hysteroscopy visualized two endometrial polyps. Surgical hysteroscopy was performed with The Integrated Bigatti Shaver (IBS®). The IBS® consists in a 6° angle telescope with an integrated sheath and a working channel in which a rigid shaver system is inserted.
Source: The Journal of Minimally Invasive Gynecology - Category: OBGYN Authors: Source Type: research
Authors: Gambacciani M, Biglia N, Cagnacci A, DI Carlo C, Caruso S, Cicinelli E, DE Leo V, Farris M, Gambera A, Guaschino S, Lanzone A, Paoletti AM, Russo N, Vicariotto F, Villa P, Volpe A Abstract In the last decade the risk benefits ratio of HRT has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausel Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause Society,...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research
CONCLUSIONS: Overall, these results suggest that the combined application of E2 and P can be a new effective strategy for hormone replacement therapy after treatment of cervical adenocarcinoma. PMID: 28975965 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
A systematic review and meta-analysis were conducted to examine the effect of growth hormone replacement therapy (GHRT) on the recurrence of craniopharyngioma in children.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Literature Reviews Source Type: research
Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured. Cardiac computed tomography (CT) determined the Agatston score, dividing t...
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: Original Articles Source Type: research
CONCLUSION: Until additional studies are performed, the risks and benefits must be weighed on an individual basis with consideration of prophylaxis when a decision is made to continue these medications in the perioperative period. Part of this decision making includes the risk of fetal harm in an unwanted pregnancy in preparation for nonobstetric surgery versus an increased risk of venous thromboembolism. PMID: 28969534 [PubMed - as supplied by publisher]
Source: Current Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Clin Pharmacol Source Type: research
Authors: Witkowska-Sędek E, Stelmaszczyk-Emmel A, Kucharska A, Demkow U, Pyrżak B Abstract Growth hormone and insulin-like growth factor-1 (IGF-1) play a crucial role in the regulation of bone turnover. Adequate vitamin D status supports proper bone remodeling, leading to normal longitudinal bone growth and normal peak bone mass. The aim of this study was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) in children and adolescents with growth hormone deficiency at baseline and during recombinant human growth hormone (rh...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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