Assessment of Drug –Drug Interaction Potential Between Atorvastatin and LCZ696, A Novel Angiotensin Receptor Neprilysin Inhibitor, in Healthy Chinese Male Subjects

ConclusionsWhile atorvastatin had no significant impact on the pharmacokinetics of LCZ696 analytes upon co-administration, theCmax of atorvastatin and its metabolites increased twofold, with a marginal increase in AUC (<1.3-fold). Multiple-dose administration of LCZ696 200  mg twice daily and atorvastatin 80 mg once daily either alone or in combination was generally safe and well tolerated in healthy subjects.

Source: European Journal of Drug Metabolism and Pharmacokinetics - March 7, 2017 Category: Drugs & Pharmacology Source Type: research