Bilateral analgesic effects of abobotulinumtoxinA (Dysport ®) following unilateral administration in the rat

DiscussionThese results suggest that unilateral administration of aboBoNT‐A results in bilateral reduction in mechanical hyperalgesia across neuropathic and inflammatory pain conditions, bilateral activation of sensory neurons being prerequisite for its expression. Future studies involving effects on other sensory modalities as well as those evaluating diffusion and migration of the toxin away from the injection site can shed light on mechanisms of this phenomenon. SignificanceThe results expand evidence on bilateral analgesic effects of aboBoNT‐A following unilateral administration across pain modalities, as the phenomenon is seen in more than one model of polyneuropathy as well as in a model of chronic inflammatory pain when the latter is rendered bilateral. The mechanism of bilateral analgesic effects of aboBoNT‐A may require activation of the peripheral sensory neurons and involve retrograde axonal transport of the toxin into the spinal cord.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research