Development of advanced biantibiotic loaded bone cement spacers for arthroplasty associated infections

Publication date: 30 April 2017 Source:International Journal of Pharmaceutics, Volume 522, Issues 1–2 Author(s): F.J. Parra-Ruíz, A. González-Gómez, M. Fernández-Gutiérrez, J. Parra, J. García-García, G. Azuara, B. De la Torre, J. Buján, B. Ibarra, L. Duocastella-Codina, M. Molina-Crisol, B. Vázquez-Lasa, J. San Román The incidence increase of infections in patients with hip or knee implants with resistant pathogens (mainly some S. coagulase-negative and gram positive bacteria) demands advanced antibiotic loaded formulations. In this paper, we report the design of new biantibiotic acrylic bone cements for in situ delivery. They include a last generation antibiotic (daptomycin or linezolid) in combination with vancomycin and are performed based on a novel modification of the Palacos R® acrylic bone cement, which is based on two components, a liquid (methyl methacrylate) and a solid (polymeric phase). Hence, the solid component of the experimental formulations include 45wt% of microparticles of poly(D,L-lactic-co-glycolic) acid, 55wt% of poly(methyl methacrylate) beads and supplements (10wt-% each) of antibiotics. These formulations provide a selective and excellent control of the local release of antibiotics during a long time period (up to 2 months), avoiding systemic dissemination. The antimicrobial activity of the advanced spacers tested against S. aureus shows that single doses would be enough for the control of the infection. In vitro biocompat...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research