Epigenetics: a link between addiction and social environment.

Epigenetics: a link between addiction and social environment.
Cell Mol Life Sci. 2017 Mar 02;:
Authors: Ajonijebu DC, Abboussi O, Russell VA, Mabandla MV, Daniels WM
Abstract
The detrimental effects of drug abuse are apparently not limited to individuals but may also impact the vulnerability of their progenies to develop addictive behaviours. Epigenetic signatures, early life experience and environmental factors, converge to influence gene expression patterns in addiction phenotypes and consequently may serve as mediators of behavioural trait transmission between generations. The majority of studies investigating the role of epigenetics in addiction do not consider the influence of social interactions. This shortcoming in current experimental approaches necessitates developing social models that reflect the addictive behaviour in a free-living social environment. Furthermore, this review also reports on the advancement of interventions for drug addiction and takes into account the emerging roles of histone deacetylase (HDAC) inhibitors in the etiology of drug addiction and that HDAC may be a potential therapeutic target at nucleosomal level to improve treatment outcomes.
PMID: 28255755 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - March 1, 2017 Category: Cytology Authors: Ajonijebu DC, Abboussi O, Russell VA, Mabandla MV, Daniels WM Tags: Cell Mol Life Sci Source Type: research