PodMed – Week of March 6, 2017

This week’s topics include testosterone supplementation, acupuncture and migraines, cardiac devices and MRI, and stem cell transplantation for MS. Program notes: 0:30 Testosterone supplementation for aging males 1:31 Looked at cognition and cardiovascular health 2:30 Plaque actually accelerated 3:30 Hypogonadism 3:50 Acupuncture and migraines 4:50 Did have a modest benefit 5:47 Stem cell transplantation in […]
Source: Johns Hopkins Medicine Weekly Health News - Category: Consumer Health News Authors: Tags: All Podcasts Heart And Vascular Nervous System Disorders Patient Care PodMed Source Type: podcasts

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Publication date: Available online 8 August 2019Source: Autoimmunity ReviewsAuthor(s): Alberto Romano, Donato Rigante, Clelia CipollaAbstractThe contribution of autoimmune phenomena to dysfunction of hypophysis or hypothalamus is far to be unraveled and also the specific pathways of hypophysitis are poorly understood until now, mostly for the pediatric population. Primary hypophysitis is rare in children and often regarded as an autoimmune disorder, following the evidence of lymphoplasmacytic infiltration in the pituitary gland, detection of anti-pituitary antibodies (APA) and anti-hypotalamus antibodies (AHA) by indirect ...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
Shanshan Zhang1, Dongli Yuan2 and Ge Tan1* 1Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2The Institute of Medical Information, Chongqing Medical University, Chongqing, China Primary systemic vasculitis can affect every structure in both the central and peripheral nervous system, causing varied neurological manifestations of neurological dysfunction. Early recognition of the underlying causes of the neurological symptoms can facilitate timely treatment and improve the prognosis. This review highlights the clinical manifestations of primary systemic vasc...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Because it has become such a frequent item in everyday meals, suggesting that something so commonplace must be fine, people often ask: Is wheat really that bad? Let’s therefore catalog the health conditions that are associated with wheat consumption. Health conditions we know with 100% certainty are caused by consumption of wheat and related grains: Celiac disease, dermatitis herpetiformis, cerebellar ataxia, “idiopathic” peripheral neuropathy, temporal lobe seizures, gluten encephalopathy, type 1 diabetes, rheumatoid arthritis, autoimmune hepatitis, autoimmune pancreatitis, tooth decay Health conditions ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune diabetes gluten-free grain-free grains wheat wheat belly Source Type: blogs
Discussion Flushing is usually thought of as a benign condition such as blushing, but can be quite irritating if it is frequent or persistent (i.e. menopausal hot flashes) or even pathologic (i.e. malignancy). “Flushing is a subjective and sensation of warmth that is accompanied by reddening of the skin anywhere on the body but favors the face, neck, and upper torso…. Flushing can be broadly divided into episodic or persistent. Episodic flashing is mediated by the release of endogenous vasoactive mediators or medications, while persistent flushing result in a fixed facial erythema with telangiectasias and cyan...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
We present a 42-year-old woman affected by an aggressive form of LH with extension to the cavernous sinus causing internal carotid artery occlusion and right sixth cranial nerve palsy. Prednisone therapy caused severe iatrogenic Cushing's syndrome, and the patient underwent transsphenoidal decompression. The histopathology report was consistent with LH. The patient was symptom free for a short period with reappearance of severe headache, diplopia, and hearing loss (middle ear inflammation) 3 months after surgery. Corticosteroids were reintroduced with the addition of azathioprine, but there was no regression of the pituita...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - Category: Neurosurgery Authors: Tags: Case Report Source Type: research
A 30-year-old man presented with 3 months of alternating hyper- and hypothermia, libido loss, hypersomnia, and headache. Neurologic examination was unremarkable. Laboratory tests revealed low serum testosterone and hypocortisolism. MRI showed hypothalamic T2 hyperintensity and contrast enhancement (figure, A). CSF analysis showed moderate lymphocytosis. Cerebral infections and malignancies were excluded. Methylprednisolone was started based on a working-diagnosis of lymphocytic hypothalamitis. After initial improvement, the patient relapsed, with MRI showing limbic involvement (figure, B). Serum and CSF screening was posit...
Source: Neurology - Category: Neurology Authors: Tags: Encephalitis, Paraneoplastic syndrome NEUROIMAGES Source Type: research
We report a case of an intracranial germ cell tumor (iGCT) that showed rapid enlargement after human chorionic gonadotropin (hCG) hormone therapy for pituitary hypogonadism. A 16-year-old boy presented with headache and was diagnosed with a suprasellar tumor. He was initially observed without surgery. Intranasal desmopressin therapy was started for central diabetes insipidus, but there was no change in the tumor size on MRI. The diagnosis of the tumor remained unknown for 4years. Levels of serum gonadotropin hormones (follicle–stimulating and luteinizing hormone) and testosterone progressively decreased, and the pati...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
A 25-year-old young man presented to our emergency room with a 3-month history of progressive headache and being easily tired. The familial and personal history of the patient was not significant. On examination, he appeared generally weak. The neurological examination revealed no visual defects, decreased muscle power, or other neurological deficits. Laboratory studies showed normocytic anemia with serum hemoglobin 12.7 g/dL. Magnetic resonance imaging (MRI) of brain was performed, which disclosed a 1.9 cm sellar mass that caused compression and mild elevation of the optic chiasm. The diagnosis of pituitary macroadenoma w...
Source: Neurosurgery Quarterly - Category: Neurosurgery Tags: Case Reports Source Type: research
Abstract Giant prolactinomas (gPRLomas) are rare tumors of the lactotroph defined by an unusually large size (>4 cm) and serum PRL levels>1000 ng/mL. The purpose of this study is to characterize the clinical spectrum of gPRLomas comparing them with non-giant prolactinomas. This is a retrospective study at a large referral center. Data from patients harboring gPRLomas and macroprolactinomas were retrieved from medical records of the Prolactinoma Clinic. Analysis was focused on clinical, biochemical, and tumor volume characteristics, as well as on the response to treatment with dopamine agonists. Amo...
Source: Endocrine - Category: Endocrinology Source Type: research
We report an Arab family with four affected XX siblings. The eldest presented with abdominal pain and was diagnosed with a retroperitoneal malignant mixed germ cell tumour. She was hypertensive and hypogonadal. One sibling presented with headache due to hypertension while the other two siblings were diagnosed with hypertension on a routine school check. A homozygous R96Q missense mutation in P450c17 was detected in the index case who had primary amenorrhea and lack of secondary sexual characters at 17 years. The middle two siblings were identical twins and had no secondary sexual characters at the age of 14. All siblings h...
Source: Diabetes Metab - Category: Endocrinology Authors: Tags: Endocrinol Diabetes Metab Case Rep Source Type: research
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