Leukemia Inhibitory Factor Promotes Aggressiveness of Chordoma.

Leukemia Inhibitory Factor Promotes Aggressiveness of Chordoma. Oncol Res. 2017 Feb 28;: Authors: Gulluoglu S, Sahin M, Tuysuz EC, Yaltirik CK, Kuskucu A, Ozkan F, Sahin F, Ture U, Bayrak OF Abstract Chordomas are rare tumors of the spine and skull base that are locally destructive and resistant to chemo- and radiation therapy, with a poor prognosis and limited therapeutic options. Chordoma patients have a long life expectancy with high mortality from the disease. Cancer stem cells, which are known to exist in chordomas, have extensive proliferative and self-renewal potential, and are responsible for maintaining tumor heterogeneity along with chemotherapy and radiotherapy resistance. The leukemia inhibitory factor has multiple functions in stem-cell biology, the immune response, and cancer, and is potentially a key molecule that allows cancer stem cells to self-renew. The purpose of this study was to determine whether the leukemia inhibitory factor increases the aggressive traits of chordoma cells and leads to a poor prognosis in patients. Twenty skull-base chordoma samples were treated with the leukemia inhibitory factor and functional tests were done. Cells were checked for levels of leukemia inhibitory factor and a correlation with clinicopathological features. The whole transcriptome microarray was used to observe changes in gene expression. We observed increased migration, invasion, tumorosphere formation, colony formation, epit...
Source: Oncology Research - Category: Cancer & Oncology Tags: Oncol Res Source Type: research