The Effect of APOE ε4 Allele on Cholinesterase Inhibitors in Patients With Alzheimer Disease: Evaluation of the Feasibility of Resting State Functional Connectivity Magnetic Resonance Imaging.
The Effect of APOE ε4 Allele on Cholinesterase Inhibitors in Patients With Alzheimer Disease: Evaluation of the Feasibility of Resting State Functional Connectivity Magnetic Resonance Imaging.
Alzheimer Dis Assoc Disord. 2014 Apr-Jun;28(2):122-7
Authors: Wang L, Day J, Roe CM, Brier MR, Thomas JB, Benzinger TL, Morris JC, Ances BM
Abstract
This work is to determine whether apolipoprotein E (APOE) genotype modulates the effect of cholinesterase inhibitor (ChEI) treatment on resting state functional connectivity magnetic resonance imaging (rs-fcMRI) in patients with Alzheimer disease (AD). We retrospectively studied very mild and mild AD participants who were treated (N=25) or untreated (N=19) with ChEIs with respect to rs-fcMRI measure of 5 resting state networks (RSNs): default mode, dorsal attention (DAN), control (CON), salience (SAL), and sensory motor. For each network, a composite score was computed as the mean of Pearson correlations between pairwise time courses extracted from areas comprising this network. The composite scores were analyzed as a function of ChEI treatment and APOE ε4 allele. Across all participants, significant interactions between ChEI treatment and APOE ε4 allele were observed for all 5 RSNs. Within APOE ε4 carriers, significantly greater composite scores were observed in the DAN, CON, and SAL for treated compared with untreated participants. Within APOE ε4 noncarriers, treated and untreated participan...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research