Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species

AbstractIriomoteolides-9a (1) and 11a (2), new 15- and 19-membered macrolides, respectively, have been isolated from the marine dinoflagellateAmphidinium species (strain KCA09052). Compounds1 and2 were obtained from the extracts of the algal cells inoculated in the PES and TKF seawater medium, respectively. The structures of1 and2 were assigned on the basis of detailed NMR analyses. Compounds1 and2 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa cells.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research